| Piroxicam-induced hepatic and renal histopathological changes in mice. | |
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MedLine Citation:
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PMID: 21503258 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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METHODS: Animals were classified into a control group and 4 treated groups. Piroxicam was injected intraperitoneally using 0.3 mg/kg every day for four weeks. Each week a group of mice was sacrificed. Liver and kidneys were obtained for histological and histochemical examination. Animals were classified into a control group and 4 treated groups. Piroxicam was injected intraperitoneally using 0.3 mg/kg every day for four weeks. Each week a group of mice was sacrificed. Liver and kidneys were obtained for histological and histochemical examination. RESULTS: Liver sections appeared with inflammatory cellular infiltration, vacuolated hepatocytes, dilated sinusoids, and increased number of Kupffer cells. Kidney sections appeared with some cellular inflammations. The glomeruli were shrunk resulting in widening of the urinary space. Oedema and vacuolations were noticed in the tubular cells. There was a positive correlation between these pathological changes and the increased treatment periods. Histochemical staining revealed that glycogen and protein contents had decreased in the hepatocytes. This depletion worsened gradually in liver cells after two, three, and four weeks. Similar depletion of the glycogen content was observed in kidney tissue. However, protein content appeared to be slightly decreased in the kidney tubules and glomeruli. Incensement of coarse chromatin in the nuclei of hepatocytes, Kupffer cells and most inflammatory cells were detected by Fuelgen method. Kidney tissues appeared with a severe decrease in coarse chromatin in the nuclei. Liver sections appeared with inflammatory cellular infiltration, vacuolated hepatocytes, dilated sinusoids, and increased number of Kupffer cells. Kidney sections appeared with some cellular inflammations. The glomeruli were shrunk resulting in widening of the urinary space. Oedema and vacuolations were noticed in the tubular cells. There was a positive correlation between these pathological changes and the increased treatment periods. Histochemical staining revealed that glycogen and protein contents had decreased in the hepatocytes. This depletion worsened gradually in liver cells after two, three, and four weeks. Similar depletion of the glycogen content was observed in kidney tissue. However, protein content appeared to be slightly decreased in the kidney tubules and glomeruli. Incensement of coarse chromatin in the nuclei of hepatocytes, Kupffer cells and most inflammatory cells were detected by Fuelgen method. Kidney tissues appeared with a severe decrease in coarse chromatin in the nuclei. CONCLUSION: Piroxicam has a time-dependent toxic effect on both liver and kidney tissues. |
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Authors:
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Hossam Ebaid; Mohamed A Dkhil; Mohamed A Danfour; Amany Tohamy; Mohamed S Gabry |
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Publication Detail:
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Type: Journal Article Date: 2007-06-01 |
Journal Detail:
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Title: The Libyan journal of medicine Volume: 2 ISSN: 1993-2820 ISO Abbreviation: Libyan J Med Publication Date: 2007 |
Date Detail:
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Created Date: 2011-04-19 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101299403 Medline TA: Libyan J Med Country: Sweden |
Other Details:
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Languages: eng Pagination: 82-9 Citation Subset: - |
Affiliation:
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Zoology Department, Faculty of Science, El-Minia University, Egypt. |
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