Document Detail

Piretanide, a potassium stable diuretic, in the treatment of essential hypertension.
MedLine Citation:
PMID:  6394349     Owner:  NLM     Status:  MEDLINE    
In a randomized, double blind, parallel group study in out patients with mild to moderate essential hypertension the effects of piretanide on serum electrolytes and on blood pressure were compared with those of triamterene alone and the combination piretanide + triamterene. 136 patients entered the study; 18 patients did not fulfill the inclusion criteria (RRdiast was below 95 mmHg or above 120 mmHg) at the end of the placebo period, 6 dropped out due to side effects, and 1 due to lack of efficacy. Data from 1 patient were not evaluated because the patient did not come regularly for checkups. The results for 110 patients were analyzed. Piretanide 6 mg b.d. and piretanide 6 mg + triamterene 50 mg b.d. produced a significant reduction both in supine and erect blood pressure, which was evident at 2 weeks and which increased over the ensuing 12 week trial period. A mean maximal fall of 16.5% was noted in the piretanide group and 15% in the piretanide + triamterene group. Triamterene alone (50 mg b.d.) also reduced diastolic and systolic blood pressures but the reduction was significantly less (diastolic blood pressure) than in both the piretanide groups, and it showed a more rapid return to pretreatment level during a placebo washout phase at the end of the study. A reduction in standing diastolic blood pressure below 95 mmHg was attained in 84% of patients in the piretanide group, 82% in the piretanide + triamterene group and in only 58% of the triamterene group. There were no significant changes within groups nor differences between the three groups in serum potassium or magnesium.(ABSTRACT TRUNCATED AT 250 WORDS)
M Verho; B Rangoonwala; W Dols; U Fratzer; J Kaczynski; W Mühlhäusler
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  27     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1984  
Date Detail:
Created Date:  1985-02-26     Completed Date:  1985-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  407-14     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Body Weight / drug effects
Calcium / blood
Clinical Trials as Topic
Diuretics / adverse effects,  therapeutic use*
Double-Blind Method
Hypertension / drug therapy*,  physiopathology
Magnesium / blood
Middle Aged
Potassium / blood*
Pulse / drug effects
Random Allocation
Sulfonamides / adverse effects,  therapeutic use*
Triamterene / adverse effects,  therapeutic use
Reg. No./Substance:
0/Diuretics; 0/Sulfonamides; 396-01-0/Triamterene; 55837-27-9/piretanide; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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