Document Detail

Pirenzepine treatment in urticaria-angioedema syndrome caused by adverse reactions to foods.
MedLine Citation:
PMID:  2573259     Owner:  NLM     Status:  MEDLINE    
An increased gastroenteric mucosal permeability is generally considered a pathophysiological mechanism in the urticaria-angioedema syndrome caused by adverse reactions to foods. Since pirenzepine, an antimuscarinic receptor drug, exerts a cytoprotective activity on digestive mucosa, the authors evaluated the clinical efficacy of pirenzepine and terfenadine (antihistamine), alone or associated, in the treatment of patients with urticaria-angioedema syndrome due to food allergy. Furthermore, additional endoscopy and biopsy studies were performed in order to provide experimental evidence about the cytoprotective activity of this treatment. The results of the present investigation confirm the clinical efficacy, with improvement of histological parameters, of pirenzepine treatment in adverse reactions to foods, as previously demonstrated by our group, and suggest further investigations on the functional mucosal impairment hypothesized in this pathological condition.
G Ciprandi; A Perasso; G Marenco; R Santucci; P Buffa; R Cheli; G W Canonica
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  17     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    1989 Jul-Aug
Date Detail:
Created Date:  1989-12-20     Completed Date:  1989-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  IM    
Semeiotica Medica R & Allergy Centre, Genoa, Italy.
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MeSH Terms
Angioedema / drug therapy*,  etiology,  pathology
Benzhydryl Compounds / therapeutic use
Drug Evaluation
Food Hypersensitivity / drug therapy*,  pathology
Gastric Mucosa / metabolism,  pathology
Histamine H1 Antagonists / therapeutic use
Intestinal Absorption
Intestinal Mucosa / metabolism,  pathology
Middle Aged
Pirenzepine / therapeutic use*
Reg. No./Substance:
0/Benzhydryl Compounds; 0/Histamine H1 Antagonists; 28797-61-7/Pirenzepine; 50679-08-8/Terfenadine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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