| Pirenzepine treatment in urticaria-angioedema syndrome caused by adverse reactions to foods. | |
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MedLine Citation:
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PMID: 2573259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increased gastroenteric mucosal permeability is generally considered a pathophysiological mechanism in the urticaria-angioedema syndrome caused by adverse reactions to foods. Since pirenzepine, an antimuscarinic receptor drug, exerts a cytoprotective activity on digestive mucosa, the authors evaluated the clinical efficacy of pirenzepine and terfenadine (antihistamine), alone or associated, in the treatment of patients with urticaria-angioedema syndrome due to food allergy. Furthermore, additional endoscopy and biopsy studies were performed in order to provide experimental evidence about the cytoprotective activity of this treatment. The results of the present investigation confirm the clinical efficacy, with improvement of histological parameters, of pirenzepine treatment in adverse reactions to foods, as previously demonstrated by our group, and suggest further investigations on the functional mucosal impairment hypothesized in this pathological condition. |
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Authors:
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G Ciprandi; A Perasso; G Marenco; R Santucci; P Buffa; R Cheli; G W Canonica |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Allergologia et immunopathologia Volume: 17 ISSN: 0301-0546 ISO Abbreviation: Allergol Immunopathol (Madr) Publication Date: 1989 Jul-Aug |
Date Detail:
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Created Date: 1989-12-20 Completed Date: 1989-12-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370073 Medline TA: Allergol Immunopathol (Madr) Country: SPAIN |
Other Details:
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Languages: eng Pagination: 189-92 Citation Subset: IM |
Affiliation:
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Semeiotica Medica R & Allergy Centre, Genoa, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angioedema / drug therapy*, etiology, pathology Benzhydryl Compounds / therapeutic use Drug Evaluation Female Food Hypersensitivity / drug therapy*, pathology Gastric Mucosa / metabolism, pathology Histamine H1 Antagonists / therapeutic use Humans Intestinal Absorption Intestinal Mucosa / metabolism, pathology Male Middle Aged Pirenzepine / therapeutic use* Terfenadine |
| Chemical | |
Reg. No./Substance:
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0/Benzhydryl Compounds; 0/Histamine H1 Antagonists; 28797-61-7/Pirenzepine; 50679-08-8/Terfenadine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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