Document Detail

Piracetam for fetal distress in labour.
MedLine Citation:
PMID:  22696322     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Piracetam is thought to promote the metabolism of brain cells when they are hypoxic. It has been used to prevent adverse effects of fetal distress.
OBJECTIVES: The objective of this review was to assess the effects of piracetam for suspected fetal distress in labour on method of delivery and perinatal morbidity.
SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (15 February 2012).
SELECTION CRITERIA: Randomised trials of piracetam compared with placebo or no treatment for suspected fetal distress in labour.
DATA COLLECTION AND ANALYSIS: Both review authors assessed eligibility and trial quality.
MAIN RESULTS: One study of 96 women was included. Piracetam compared with placebo was associated with a trend to reduced need for caesarean section (risk ratio 0.57, 95% confidence interval 0.32 to 1.03). There were no statistically significant differences between the piracetam and placebo group for neonatal morbidity (measured by neonatal respiratory distress) or Apgar score.
AUTHORS' CONCLUSIONS: There is not enough evidence to evaluate the use of piracetam for fetal distress in labour.
G Justus Hofmeyr; Regina Kulier
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-06-13
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  6     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-14     Completed Date:  2012-08-13     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD001064     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, East London Hospital Complex, University of the Witwatersrand, University of FortHare, Eastern Cape Department of Health, East London, South Africa.
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MeSH Terms
Apgar Score
Cesarean Section / utilization
Delivery, Obstetric
Fetal Distress / drug therapy*
Labor, Obstetric*
Neuroprotective Agents / therapeutic use*
Piracetam / therapeutic use*
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Neuroprotective Agents; 7491-74-9/Piracetam
Update Of:
Cochrane Database Syst Rev. 2002;(1):CD001064   [PMID:  11869588 ]

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