| Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis. | |
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MedLine Citation:
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PMID: 16419161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-gamma (PPARgamma) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1beta (IL-1beta) and IL-10 were determined. Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1beta and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1beta and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1beta and to the overexpression of HSP70. PPARgamma ligands could represent a new therapeutic option in the treatment of AP. |
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Authors:
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Peter C Konturek; Artur Dembinski; Zygmunt Warzecha; Grzegorz Burnat; Piotr Ceranowicz; Eckhart G Hahn; Marcin Dembinski; Romana Tomaszewska; Stanislaw J Konturek |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 11 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2006-01-18 Completed Date: 2006-03-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 6322-9 Citation Subset: IM |
Affiliation:
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First Department of Medicine, University Erlangen-Nurnberg, Erlangen, Germany. peter.konturek@med1.imed.uni-erlangen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caerulein / toxicity* DNA / biosynthesis Dose-Response Relationship, Drug HSP70 Heat-Shock Proteins / genetics, metabolism Interleukin-1 / blood, genetics Interleukin-10 / blood Lipase / blood Male PPAR gamma / metabolism* Pancreas / blood supply, drug effects*, pathology, physiology Pancreatitis / chemically induced*, pathology Protective Agents* / metabolism, pharmacology Rats Rats, Wistar Regional Blood Flow Thiazolidinediones* / metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; 0/Interleukin-1; 0/PPAR gamma; 0/Protective Agents; 0/Thiazolidinediones; 111025-46-8/pioglitazone; 130068-27-8/Interleukin-10; 17650-98-5/Caerulein; 9007-49-2/DNA; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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