Document Detail


Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat.
MedLine Citation:
PMID:  12871756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear hormone receptor superfamily that is involved in the control of inflammation and carcinogenesis. We determined the effect of the specific PPAR-gamma ligand, pioglitazone (5-40 mg/kg intragastrically), on the healing of acetic-acid gastric ulcers in rats. At day 8 after ulcer induction, the ulcer area, the gastric blood flow and mucosal expression of proinflammatory cytokines such as interleukin-1beta, tumour necrosis factor alpha (TNF-alpha) and cyclooxygenase-1, cyclooxygenase-2, constitutive nitric oxide synthase (cNOS), inducible nitric oxide synthase (iNOS) and heat shock protein 70 (HSP70) was determined. Pioglitazone reduced the area of gastric ulcers and raised significantly the gastric blood flow at the ulcer margin and downregulated the mRNA for interleukin-1beta, TNF-alpha, cyclooxygenase-2 and iNOS while cyclooxygenase-1 mRNA was not affected. The expression of PPAR-gamma mRNA was increased in the ulcerated gastric mucosa. We conclude that pioglitazone accelerates the healing of preexisting gastric ulcers due to the hyperemia at ulcer margin and the anti-inflammatory action including suppression of interleukin-1beta, TNF-alpha, cyclooxygenase-2 and iNOS and by an overexpression of HSP70.
Authors:
Peter C Konturek; Tomasz Brzozowski; Joanna Kania; Stanislaw J Konturek; Slawomir Kwiecien; Robert Pajdo; Eckhart G Hahn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  472     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-21     Completed Date:  2004-03-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  213-20     Citation Subset:  IM    
Affiliation:
First Department of Medicine, University Erlangen-Nuernberg, Erlangen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ligands
Male
Prostaglandin-Endoperoxide Synthases / metabolism
Rats
Rats, Wistar
Receptors, Cytoplasmic and Nuclear / metabolism*
Stomach Ulcer / drug therapy*,  metabolism*,  pathology
Thiazolidinediones / metabolism*,  therapeutic use*
Transcription Factors / metabolism*
Chemical
Reg. No./Substance:
0/Ligands; 0/Receptors, Cytoplasmic and Nuclear; 0/Thiazolidinediones; 0/Transcription Factors; 111025-46-8/pioglitazone; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

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