Document Detail


Pioglitazone inhibits angiotensin II-induced atrial Fibroblasts proliferation via NF-κB/TGF-β1/TRIF/TRAF6 pathway.
MedLine Citation:
PMID:  25152439     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The exact mechanisms underlying inhibitory effects of pioglitazone (Pio) on Angiotensin II (AngII)-induced atrial fibrosis are complex and remain largely unknown. In the present study, we examined the effect of Pio on AngII-induced mice atrial fibrosis in vivo and atrial fibroblasts proliferation in vitro. In vivo study showed that AngII infusion induced atrial fibrosis and increased expressions of Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) and tumor necrosis factor receptor associated factor 6 (TRAF6) in mice models. However, those effects could be attenuated by Pio (P<0.01). As for in vitro experiment, Pio suppressed AngII-induced atrial fibroblasts proliferation via nuclear factor-κB/transforming growth factor-β1/TRIF/TRAF6 signaling pathway in primary cultured mice atrial fibroblasts (P<0.01). In conclusion, suppression of Pio on AngII-induced atrial fibrosis might be related with its inhibitory effects on above signaling pathway.
Authors:
Xiao-Qing Chen; Xu Liu; Quan-Xing Wang; Ming-Jian Zhang; Meng Guo; Fang Liu; Wei-Feng Jiang; Li Zhou
Related Documents :
12023809 - Ftir and uv spectroscopy studies of triplex formation between pyrimidine methoxyethylph...
11705829 - Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor...
8734469 - Effect of selective beta-adrenoceptor stimulation on ucp synthesis in primary cultures ...
20211549 - Surface protein composition and concentration of whey protein isolate-stabilized oil-in...
7728569 - Construction and expression in tumor cells of a recombinant vaccinia virus encoding hum...
11671469 - Novel syntheses of alpha,beta-unsaturated esters, alpha,beta-unsaturated gamma-lactones...
17323859 - Inhibition of cytokine-induced expression of t-cell cytokines by antihistamines.
15071119 - Odors detected by mice deficient in cyclic nucleotide-gated channel subunit a2 stimulat...
10207889 - Expression of an engineered form of recombinant procollagen in mouse milk.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-21
Journal Detail:
Title:  Experimental cell research     Volume:  -     ISSN:  1090-2422     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell...
Next Document:  Mitf regulates osteoclastogenesis by modulating NFATc1 activity.