| Pioglitazone improves ventricular diastolic function in patients with diabetes mellitus: a tissue Doppler study. | |
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MedLine Citation:
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PMID: 20821932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Pioglitazone treatment in type 2 diabetes mellitus produced significant improvements in glycaemic control, plasma lipids, blood pressure and inflammation. The aim of this study was to investigate the effect of pioglitazone on systolic and diastolic function in diabetic patients. METHODS AND RESULTS: Forty-nine diabetic patients were included in the study. The patients had never received thiazolidinedione therapy before. Clinical and echocardiographic variables were measured. 30 mg pioglitazone were administered. The patients were followed up for six months and all the measurements were re-evaluated for comparison. Body mass index (BMI) significantly increased after treatment. Fasting glucose, HbA1c and systolic blood pressure decreased. Insulin resistance improved and the HOMA-IR index decreased after pioglitazone treatment. Mean aortic diameter, left atrial systolic and diastolic volumes significantly decreased after therapy. Among diastolic function variables mitral E wave, E/A, ejection time and pulmonary vein peak reverse flow velocity (PVA) significantly increased whereas isovolumetric relaxation time (IVRT), isovolumetric contraction time (IVCT), deceleration time, E/E' and pulmonary vein late systolic flow (PVS2) decreased after pioglitazone therapy. Among tissue Doppler variables early (E) ventricular inflow velocities measured from the tricuspid lateral annulus, the mitral septal and lateral annulus, the anterior, inferior and posterior free wall significantly increased. Late (A) ventricular inflow velocities measured from the anterior, inferior free wall and the mitral septal annulus also increased. CONCLUSION: Pioglitazone treatment in type 2 diabetes mellitus produced significant improvements in measures of glycaemic control and diastolic ventricular function. |
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Authors:
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Serkan Ordu; Hakan Ozhan; Recai Alemdar; Mesut Aydin; Cengiz Basar; Onur Caglar; Mehmet Yazici; Subhan Yalcin |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cardiologica Volume: 65 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 401-6 Citation Subset: IM |
Affiliation:
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Dept. of Cardiology, Duzce University, Düzce Medical School, Konuralp Düzce, Turkey. orduserkan@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Blood Glucose / drug effects Blood Pressure / drug effects Body Mass Index Diabetes Mellitus, Type 2 / drug therapy*, physiopathology, ultrasonography* Diastole / drug effects* Echocardiography, Doppler* Female Humans Hypoglycemic Agents / therapeutic use* Insulin Resistance Male Middle Aged Myocardial Contraction / drug effects Systole / drug effects* Thiazolidinediones / therapeutic use* Ventricular Dysfunction, Left / drug therapy*, physiopathology, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Thiazolidinediones; 111025-46-8/pioglitazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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