Document Detail

Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress.
MedLine Citation:
PMID:  20064642     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to determine pioglitazone treatment restores endothelial function in hypertensive patients with impaired glucose tolerance (IGT).
METHODS AND RESULTS: We evaluated the effects of pioglitazone treatment for 12 weeks on forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside in 34 hypertensive patients with IGT who were randomly divided into a pioglitazone group (n=17) and an amlodipine monotherapy group (n=17) and in 34 healthy subjects. Pioglitazone, but not amlodipine, increased the FBF response to acetylcholine and decreased urinary excretion of 8-hydroxy-2'-deoxyguanosine. Pioglitazone did not alter sodium nitroprusside-stimulated vasodilation. NG-monomethyl-L-arginine abolished the augmentation of FBF response to acetylcholine after pioglitazone treatment. The increase in maximal FBF response to acetylcholine correlated with the decrease in urinary excretion of 8-hydroxy-2'-deoxyguanosine.
CONCLUSION: Pioglitazone improved endothelial function in hypertensive patients with IGT through an increase in nitric oxide bioavailability by, in part, a decrease in oxidative stress.
Takayuki Hidaka; Keigo Nakagawa; Chikara Goto; Junko Soga; Yuichi Fujii; Takaki Hata; Naomi Idei; Noritaka Fujimura; Kazuaki Chayama; Yasuki Kihara; Yukihito Higashi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-04
Journal Detail:
Title:  Atherosclerosis     Volume:  210     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  521-4     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
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MeSH Terms
Acetylcholine / pharmacology
Amlodipine / pharmacology
Case-Control Studies
Endothelium, Vascular / pathology*
Glucose / metabolism*
Glucose Tolerance Test
Hypertension / drug therapy*
Hypoglycemic Agents / pharmacology
Middle Aged
Nitroprusside / pharmacology
Oxidative Stress*
Thiazolidinediones / pharmacology*
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Hypoglycemic Agents; 0/Thiazolidinediones; 0/Vasodilator Agents; 111025-46-8/pioglitazone; 15078-28-1/Nitroprusside; 50-99-7/Glucose; 51-84-3/Acetylcholine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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