| Pioglitazone improves the cardiovascular profile in patients with uncomplicated systemic lupus erythematosus: a double blind randomized clinical trial. | |
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MedLine Citation:
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PMID: 21993383 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: We studied the effect of pioglitazone on insulin levels, inflammation markers, high-density lipoprotein (HDL) composition and subclasses distribution, in young women with uncomplicated systemic lupus erythematosus (SLE). Methods: This double-blind trial included 30 premenopausal women (30 ±8 years old) with SLE, who were randomized to pioglitazone (30 mg/day) or placebo treatment for 3 months. Plasma and HDL lipids were determined by colorimetric enzymatic assays, insulin by radioimmunometric assay, inflammation by immunonephelometry and HDL size and subclasses distribution by a native 4-30% polyacrylamide gradient gel electrophoresis. Results: Compared with placebo, pioglitazone significantly increased HDL-cholesterol plasma levels (14.2%), reduced fasting insulin plasma levels (23.6%) and the homeostasis model assessment-insulin resistance (31.7%). C-reactive protein (70.9%) and serum amyloid A (34.9%) were also significantly reduced with the pioglitazone use, whereas the HDL particle size was increased (8.80 nm vs. 8.95 nm; p = 0.044) by changes in the distribution of HDL(2b), HDL(3b), and HDL(3c) subclasses. The change in HDL size correlated with a rise in free and cholesterol-ester content in the HDL particles. Conclusion: Pioglitazone significantly enhanced insulin sensitivity, reduced inflammation, and modified HDL characteristics, suggesting a potential beneficial effect of this drug in patients with SLE with a risk to develop cardiovascular disease. Trial registration: This trial is registered at ClinicalTrials.gov Protocol Registration System, with the number NCT01322308. |
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Authors:
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J G Juárez-Rojas; A X Medina-Urrutia; E Jorge-Galarza; N A Caracas-Portilla; R Posadas-Sánchez; G C Cardoso-Saldaña; M V Goycochea-Robles; L H Silveira; L Lino-Pérez; J Mas-Oliva; O A Pérez-Méndez; C Posadas-Romero |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
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Title: Lupus Volume: - ISSN: 1477-0962 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204265 Medline TA: Lupus Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Endocrinology Department, National Institute of Cardiology ''Ignacio Chávez'', Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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