| Ping-pong transmission of herpes simplex virus 1 following corneal transplantation. | |
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MedLine Citation:
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PMID: 22532041 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Primary corneal graft failure (PCGF) after penetrating keratoplasty (PKP) despite good endothelial cell count of the transplant in organ culture rarely occurs in young patients. A herpes simplex virus type I (HSV-1) infection (transmission through the donor or reactivation by the patient) can lead to PCGF. METHODS: We report on a 43-year-old man with pellucid marginal corneal degeneration and neurodermitis, who was underwent penetrating keratoplasty (PKP) on the left eye after acute corneal hydrops in both eyes. A repeat keratoplasty (re-PKP) had to be performed 15 days after the first PKP due to a primary graft failure. A re-re-PKP with simultaneous amniotic membrane transplantation (as a patch) and partial lateral tarsorrhaphy became necessary 4 months after the re-PKP due to melting on the edge of the graft with persistent epithelial defects. RESULTS: After intensive cooperation between ophthalmologists and pathologists the histopathological findings showed keratocytes which reacted immunohistochemically positive for HSV-1 antigens in the deep corneal stroma of both corneal grafts. The excised own cornea of the patient was histopathologically negative but the DNA-PCR for HSV-1 was weakly positive. After adequate topical and systemic antiviral therapy the third graft has remained clear for 12 months. CONCLUSION: In cases of PCGF after normal risk corneal transplantation the possibility of HSV infection should always be considered. After confirmation of the diagnosis with the help of the immunohistochemical tests and/or PCR, an adequate treatment with antiviral medication (acyclovir tablets 2 × 400 mg for more than 1 year) should be administered to the patient after repeat PKP. |
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Authors:
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E Stavridis; Z Gatzioufas; A Hasenfus; M Sauter; S Smola; B Seitz |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-25 |
Journal Detail:
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Title: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft Volume: - ISSN: 1433-0423 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206148 Medline TA: Ophthalmologe Country: - |
Other Details:
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Languages: GER Pagination: - Citation Subset: - |
Affiliation:
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Klinik für Augenheilkunde, Universitätsklinikum des Saarlandes (UKS), Kirrberger Str. 1, 66424, Homburg/Saar, Deutschland, evangelos.stavridis@uks.eu. |
Vernacular Title:
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Ping-Pong-Transmission von Herpes-simplex-Virus 1 nach Hornhauttransplantation. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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