Document Detail

Pineapple juice labeled with gadolinium: a convenient oral contrast for magnetic resonance cholangiopancreatography.
MedLine Citation:
PMID:  15999215     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to prepare in vitro a pineapple juice (PJ) solution labeled with a minimal gadolinium concentration working as a negative contrast agent in heavily T2-weighted imaging and to assess that solution in vivo as a negative oral contrast agent for magnetic resonance cholangiopancreatography (MRCP). Three PJs were compared in vitro according to their T2. Increasing concentrations of gadolinium (Gd)-DOTA in PJ were assessed in vitro for T2 reduction. Single-shot turbo spin echo T2-weighted MR cholangiopancreatograms were obtained for 35 patients with suspected biliopancreatic duct disease, before and after ingestion of the PJ/Gd-DOTA solution. Signal intensity (SI) measurements of gastroduodenal lumens, pancreatobiliary ducts, and image quality scores were obtained systematically before and after contrast ingestion. The in vitro selected Gd-DOTA concentration in the PJ was 2.76 mmol/l. Ingestion of 180 ml of PJ labeled with 1 ml of Gd-DOTA eliminated efficiently the gastroduodenal SI in MRCP, improving significantly the rates of complete visualization of the pancreatobiliary ducts (P<0.01) and the MRCP image quality scores (P<0.05). All patients easily ingested the contrast solution and found the solution palatable. PJ labeled with gadolinium constituted an efficient and convenient negative oral contrast agent for MRCP.
Emmanuel Coppens; Thierry Metens; Catherine Winant; Celso Matos
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2005-07-06
Journal Detail:
Title:  European radiology     Volume:  15     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-19     Completed Date:  2006-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2122-9     Citation Subset:  IM    
Department of Radiology, Division of Magnetic Resonance, Hôpital Erasme, Université Libre de Bruxelles, 808 route de Lennik, 1070, Brussels, Belgium.
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MeSH Terms
Administration, Oral
Cholangiopancreatography, Magnetic Resonance / methods*
Common Bile Duct / metabolism,  radiography
Contrast Media / administration & dosage*,  metabolism
Duodenum / metabolism,  radiography
Hepatic Duct, Common / metabolism,  radiography
Heterocyclic Compounds / administration & dosage*,  metabolism
Image Processing, Computer-Assisted
Middle Aged
Muscle Relaxation / drug effects
Organometallic Compounds / administration & dosage*,  metabolism
Pancreatic Ducts / metabolism,  radiography
Plant Preparations
Radiographic Image Enhancement
Reproducibility of Results
Stomach / metabolism,  radiography
Reg. No./Substance:
0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 0/Plant Preparations; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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