Document Detail

Pineal and nonpineal supratentorial primitive neuroectodermal tumors.
MedLine Citation:
PMID:  10550590     Owner:  NLM     Status:  MEDLINE    
Pineal region supratentorial primitive neuroectodermal tumors (SPNETs; pineoblastomas) and nonpineal SPNETs are rare tumors that historically have carried a very poor prognosis. With multimodality therapy, including maximal surgical resection, craniospinal radiation therapy and chemotherapy, the survival for patients with pineal PNETs has significantly improved. Chemotherapy alone, at least in conventional doses, appears to be insufficient treatment for younger children with pineoblastomas, in whom there is almost universal rapid tumor progression and death. Survival of patients with nonpineal SPNETs remains in the order of 30-35% despite multimodality therapy. Unlike those with pineal SPNETs, a significant percentage of infants with nonpineal SPNETs who undergo gross total surgical resection followed by chemotherapy will be long-term survivors. This article gives an overview of the natural history, prognostic factors and treatment of both pineal and nonpineal SPNETs.
R I Jakacki
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  15     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  586-91     Citation Subset:  IM    
Children's Hospital of Pittsburgh, 3520 Fifth Avenue, Suite 205, Pittsburgh, PA 15213, USA.
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MeSH Terms
Child, Preschool
Combined Modality Therapy
Neuroectodermal Tumors, Primitive / drug therapy,  therapy*
Pineal Gland*
Supratentorial Neoplasms / drug therapy,  therapy*

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