Document Detail

Pineal muscarinic phosphoinositide response: pertussis toxin resistant signaling with very low receptor number.
MedLine Citation:
PMID:  2554898     Owner:  NLM     Status:  MEDLINE    
Autoradiography revealed very low density of muscarinic receptors in the rat pineal gland. Yet, the magnitude of phosphoinositide hydrolysis elicited with 0.1 mM carbachol was similar to that seen with 1 mM norepinephrine. The cholinergic and adrenergic phosphoinositide responses were fully additive. The cholinergic signal was insensitive to pertussis toxin both in vivo and in vitro and persisted in pineals cultured for 5 days. The data expand our previous finding on functional muscarinic acetylcholine receptors in the rat pineal gland.
J T Laitinen; T Torda; J M Saavedra
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  164     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-11     Completed Date:  1989-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  645-52     Citation Subset:  IM    
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
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MeSH Terms
Atropine / pharmacology
Carbachol / pharmacology*
Norepinephrine / pharmacology*
Organ Culture Techniques
Pertussis Toxin*
Phosphatidylinositols / metabolism*
Pineal Gland / drug effects,  metabolism*
Pirenzepine / pharmacology
Prazosin / pharmacology
Rats, Inbred Strains
Receptors, Muscarinic / drug effects,  physiology*
Signal Transduction / drug effects*
Virulence Factors, Bordetella / pharmacology*
Reg. No./Substance:
0/Phosphatidylinositols; 0/Receptors, Muscarinic; 0/Virulence Factors, Bordetella; 19216-56-9/Prazosin; 28797-61-7/Pirenzepine; 51-41-2/Norepinephrine; 51-55-8/Atropine; 51-83-2/Carbachol; EC Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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