Document Detail


Pineal muscarinic phosphoinositide response: pertussis toxin resistant signaling with very low receptor number.
MedLine Citation:
PMID:  2554898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoradiography revealed very low density of muscarinic receptors in the rat pineal gland. Yet, the magnitude of phosphoinositide hydrolysis elicited with 0.1 mM carbachol was similar to that seen with 1 mM norepinephrine. The cholinergic and adrenergic phosphoinositide responses were fully additive. The cholinergic signal was insensitive to pertussis toxin both in vivo and in vitro and persisted in pineals cultured for 5 days. The data expand our previous finding on functional muscarinic acetylcholine receptors in the rat pineal gland.
Authors:
J T Laitinen; T Torda; J M Saavedra
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  164     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-11     Completed Date:  1989-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  645-52     Citation Subset:  IM    
Affiliation:
Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atropine / pharmacology
Carbachol / pharmacology*
Male
Norepinephrine / pharmacology*
Organ Culture Techniques
Pertussis Toxin*
Phosphatidylinositols / metabolism*
Pineal Gland / drug effects,  metabolism*
Pirenzepine / pharmacology
Prazosin / pharmacology
Rats
Rats, Inbred Strains
Receptors, Muscarinic / drug effects,  physiology*
Signal Transduction / drug effects*
Virulence Factors, Bordetella / pharmacology*
Chemical
Reg. No./Substance:
0/Phosphatidylinositols; 0/Receptors, Muscarinic; 0/Virulence Factors, Bordetella; 19216-56-9/Prazosin; 28797-61-7/Pirenzepine; 51-41-2/Norepinephrine; 51-55-8/Atropine; 51-83-2/Carbachol; EC 2.4.2.31/Pertussis Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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