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Pineal germinomas with granulomatous inflammation. Report of two cases and review of the literature.
MedLine Citation:
PMID:  17140186     Owner:  NLM     Status:  In-Data-Review    
The authors report on two cases of pineal germinomas with granulomatous inflammation (granulomatous germinomas). Macroscopically, both tumors were relatively hard and grayish in color. Histological examination revealed a germinoma with multinucleated giant cells and Schaumann bodies in one case, and a germinoma with the background of acellular fibrillated matrix in the other. On immunohistochemical analysis, the granulomatous germinomas were shown to contain many macrophages, T- and B-lymphocytes, and glial fibrillary acid protein-positive cells infiltrating the specimens, compared to nongranulomatous germinomas. Analysis of Masson's trichrome staining tests showed that large areas of the granulomatous germinomas were occupied by a collagenous component; this was not the case in cases of nongranulomatous germinomas. Analysis of monoclonal anti-human Ki-67 results showed that the granulomatous germinomas had a lower score than nongranulomatous germinomas (p < 0.05, unpaired t-test), indicating that germinomas with granulomatous inflammation may have a better prognosis.
M Murakami; J Kuratsu; M Kochi; N Kunitoku; A Hashiguchi; Y Ushio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgical focus     Volume:  5     ISSN:  1092-0684     ISO Abbreviation:  Neurosurg Focus     Publication Date:  1998 Jul 
Date Detail:
Created Date:  2006-12-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896471     Medline TA:  Neurosurg Focus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e5     Citation Subset:  -    
Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan.
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