| Pineal germinomas with granulomatous inflammation. Report of two cases and review of the literature. | |
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MedLine Citation:
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PMID: 17140186 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The authors report on two cases of pineal germinomas with granulomatous inflammation (granulomatous germinomas). Macroscopically, both tumors were relatively hard and grayish in color. Histological examination revealed a germinoma with multinucleated giant cells and Schaumann bodies in one case, and a germinoma with the background of acellular fibrillated matrix in the other. On immunohistochemical analysis, the granulomatous germinomas were shown to contain many macrophages, T- and B-lymphocytes, and glial fibrillary acid protein-positive cells infiltrating the specimens, compared to nongranulomatous germinomas. Analysis of Masson's trichrome staining tests showed that large areas of the granulomatous germinomas were occupied by a collagenous component; this was not the case in cases of nongranulomatous germinomas. Analysis of monoclonal anti-human Ki-67 results showed that the granulomatous germinomas had a lower score than nongranulomatous germinomas (p < 0.05, unpaired t-test), indicating that germinomas with granulomatous inflammation may have a better prognosis. |
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Authors:
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M Murakami; J Kuratsu; M Kochi; N Kunitoku; A Hashiguchi; Y Ushio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurosurgical focus Volume: 5 ISSN: 1092-0684 ISO Abbreviation: Neurosurg Focus Publication Date: 1998 Jul |
Date Detail:
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Created Date: 2006-12-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896471 Medline TA: Neurosurg Focus Country: United States |
Other Details:
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Languages: eng Pagination: e5 Citation Subset: - |
Affiliation:
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Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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