Document Detail

Pineal cysts - a benign consequence of mild hypoxia in a near-term brain?
MedLine Citation:
PMID:  22167146     Owner:  NLM     Status:  Publisher    
Background: Pineal cysts are benign glial uniloculated or multiloculated fluid-filled sacs located in the pineal gland region. Small pineal cysts are often found incidentally in healthy adults in 1.5-10.8%. Large cysts may cause neurological problems due to pressure exertion on adjacent structures. Methods: We have used prospective, observational study of an inception cohort of 16 adolescents of mean age 21.69 years (SD=±0.87) with mild (68.7%) to moderate (31.3%) HIE: 7 girls (43.8%) and 9 (56.3%) boys, born with mean gestational age of 35.75 weeks (SD=±3.80) and mean birthweight of 2 644 g (SD=±815). HIE was confirmed by presence of abnormal CTG and/or meconium and/or Apgar scores less than 7 at 5 minutes and/or need for resuscitation and/or cord pH less than 7.2 and /or BE more than -15. The clinical assessment of HIE was done according to the Sarnat-Sarnat scoring. Neonatal data, including EEG and imaging data, were collected. Adolescents were scanned with 3T Magnetom Trio Tim, Siemens, head coil 12 channels, regular sequences and sagittal 3D magnetization-prepared rapid acquisition gradient echo (MPRAGE) sequence with voxel size 1 mm3. Neurological outcome was determined. Results: In 1 patient we found cortical dysplasia and 1 had a panic attack hence their data were omitted. In the group of 14 we have incidentally found in 5 patients a larger, asymptomatic pineal cysts with the overall incidence of 36%. Other MR findings in the group were in 50% white matter injury, in 50% thinner corpus callosum. No statistically significant difference between neonatal cUS and late follow-up MRI (p=0.881) was found. Correlation was not significant with Spearman correlation koefficient 0.201. Presence of pineal cysts was linked to thinner corpus callosum (p=0.005). Conclusions: We propose that larger pineal cyst, in the absence of other imaging findings except for thinner corpus callosum, is a benign consequence of mild hypoxia in a near-term brain. Our findings warrant a larger study.
Related Documents :
16126926 - Breast lesion detection and characterization at contrast-enhanced mr mammography: gadob...
20232406 - Unusual sonographic appearance of a huge angiomyolipoma of the liver.
16606396 - Atrial linear lesions: feasibility using cryoablation.
9442126 - Critical evaluation of the specificity of mri and tvus for differentiation of malignant...
9101106 - Temporal lobe lesion demonstrating features of dysembryoplastic neuroepithelial tumor a...
22132846 - Large cell carcinoma of the lacrimal gland diagnosed by fine needle aspiration biopsy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-14
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  32     ISSN:  0172-780X     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Panic disorder, autonomic nervous system and dissociation - changes during therapy.
Next Document:  Porous chitosan scaffold and ngf promote neuronal differentiation of neural stem cells in vitro.