Document Detail

Pineal N-acetyltransferase activity in 10-day-old rats: a paradigm for studying the developing circadian system.
MedLine Citation:
PMID:  6745194     Owner:  NLM     Status:  MEDLINE    
Pineal N-acetyltransferase (NAT) activity in 10-day-old rat pups was used to examine several aspects of the developing circadian timing system. When born and reared under constant darkness, 10-day-old animals manifested a clear daily rhythm of NAT activity whose phase was in time with the estimated circadian time of the mother (set by the lighting cycle during pregnancy). When pups were reared in constant darkness from birth by a foster mother whose circadian time was 180 degrees (12 h) out of phase with that of the natural mother, the resulting population profiles of NAT activity were arrhythmic. Analysis of the individual litter profiles from this experiment showed a variable postnatal influence of the maternal circadian system on the timing of the developing circadian system. Neither cross-fostering per se nor social interactions among litter mates contributed significantly to the apparent maternal influence. The magnitude of the postnatal maternal influence was not the same throughout development, but was most apparent during the first 5 days of life. Neonatal blinding (within 24 h of birth) did not appreciably alter the maternal influence. Extraretinal photoreception does not contribute to entrainment of the circadian clock during postnatal development, and retina-mediated photic entrainment is present by 10 days of age. The results indicate that pineal NAT activity monitored in 10-day-old rats provides a useful paradigm for studying the developing circadian system.
S M Reppert; R J Coleman; H W Heath; J R Swedlow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  115     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-09-20     Completed Date:  1984-09-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  918-25     Citation Subset:  AIM; IM    
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MeSH Terms
Acetyltransferases / metabolism*
Animals, Newborn / growth & development*
Circadian Rhythm*
Photic Stimulation
Photoreceptor Cells / physiology
Pineal Gland / enzymology*
Rats, Inbred Strains
Grant Support
Reg. No./Substance:
EC 2.3.1.-/Acetyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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