Document Detail

Pine resin and biopin ointment: effects of water-soluble fractions on cytokine production by peripheral blood neutrophils.
MedLine Citation:
PMID:  12459838     Owner:  NLM     Status:  MEDLINE    
We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used for the therapy of burns, wounds, and purulent and inflammatory diseases on spontaneous and induced synthesis of tumor necrosis factor and interleukins 1, 2, and 8 by human peripheral blood neutrophils in vitro. These preparations contain various bioactive substances producing opposite and dose-dependent immunomodulatory effects. Our results indicate that the composition and doses of preparations should be selected to achieve the maximum therapeutic effect.
A S Simbirtsev; V G Konusova; G Sh McHedlidze; B A Paramonov; V Yu Chebotarev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  134     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-12-02     Completed Date:  2003-07-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-5     Citation Subset:  IM    
Institute of High-Purity Biological Preparations, St. Petersburg.
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MeSH Terms
Biopterin / administration & dosage,  pharmacology*
Interleukins / biosynthesis*
Neutrophils / drug effects*,  metabolism
Resins, Plant / administration & dosage,  pharmacology*
Tumor Necrosis Factor-alpha / biosynthesis*
Reg. No./Substance:
0/Interleukins; 0/Ointments; 0/Resins, Plant; 0/Tumor Necrosis Factor-alpha; 22150-76-1/Biopterin; 8050-09-7/rosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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