Document Detail


Pindolol: effects on blood pressure and plasma renin activity.
MedLine Citation:
PMID:  7048878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of pindolol, other antihypertensive agents, or placebo upon plasma renin activity (PRA) was examined in five separate studies involving 249 subjects (pindolol), n = 149; propranolol, n = 43; methyldopa, n = 13; chlorthalidone, n = 16; placebo, n = 28). In addition, the subjects were stratified in for studies into low (n = 104), medium (n = 96), or high (n = 15) PRA categories according to baseline PRA and sodium excretion measurements. The response to antihypertensive therapy was analyzed in each PRA category. Pindolol and propranolol lowered PRA comparably at equivalent dosages, although this effect was not consistently observed in all studies or at all dosage levels. Methyldopa therapy was not associated with a decline in PRA and chlorthalidone elevated PRA. Pindolol and propranolol lowered both supine and erect diastolic blood pressure (BP) comparably. This effect was similar in subjects categorized as having low or medium PRA. Too few patients were studied with high PRA to derive statistically meaningful data. Pindolol lowered standing systolic BP to a greater extent than did propranolol, especially in the medium PRA category. It was concluded that pindolol, like other beta-adrenergic blockers, lowers PRA, that the effect of pindolol on diastolic BP is independent of the baseline PRA category, and that pindolol is more effective than propranolol in lowering standing systolic BP, at least in the medium PRA category.
Authors:
R J Glassock; R E Weitzman; C M Bennett; M Maxwell; B Hamilton; N Winer; W Kirkendall; L Gonasun
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  104     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-17     Completed Date:  1982-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects
Chlorthalidone / therapeutic use
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Hypertension / drug therapy*,  enzymology
Male
Methyldopa / therapeutic use
Middle Aged
Pindolol / pharmacology,  therapeutic use*
Propranolol / therapeutic use
Random Allocation
Renin / blood*
Chemical
Reg. No./Substance:
13523-86-9/Pindolol; 525-66-6/Propranolol; 555-30-6/Methyldopa; 77-36-1/Chlorthalidone; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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