Document Detail


Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expression.
MedLine Citation:
PMID:  16124054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate clinical significance of Pin1 and beta-catenin expression in colorectal cancers and to demonstrate the relationship of their expression. METHODS: The role of Pin1 and beta-catenin protein in colorectal tumorigenesis and their clinicopathologic significance were analyzed by immunohistochemistry, and the correlation between Pin1 and beta-catenin protein expressions was also studied in 124 patients with colorectal cancer who were surgically treated. RESULTS: Normal colonic epithelium either failed to express or showed focal and weak expression of Pin1 and beta-catenin. Overexpression of Pin1 and beta-catenin protein was found in 23 (18.54%) and 50 (40.3%) of 124 colorectal cancers, respectively. Overexpression of both proteins was not related to the lymph node metastasis, tumor stage and survival period after excision. Survival analysis results indicated that tumor stage was a valuable predictor of survival. Interestingly, a significant correlation was found between Pin1 and beta-catenin protein expression. CONCLUSION: Overexpression of Pin1 and beta-catenin may be closely related with the development and/or progression of colorectal carcinoma and further supports that Pin1 overexpression might contribute to the upregulation of beta-catenin.
Authors:
Chang-Jae Kim; Yong-Gu Cho; Yong-Gyu Park; Suk-Woo Nam; Su-Young Kim; Sug-Hyung Lee; Nam-Jin Yoo; Jung-Young Lee; Won-Sang Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  11     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-26     Completed Date:  2005-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5006-9     Citation Subset:  IM    
Affiliation:
Department of Pathology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul 137-701, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Colorectal Neoplasms / metabolism*,  mortality,  pathology
Cytoskeletal Proteins / metabolism*
Disease Progression
Humans
Peptidylprolyl Isomerase / metabolism*
Survival Rate
Trans-Activators / metabolism*
Up-Regulation
beta Catenin
Chemical
Reg. No./Substance:
0/CTNNB1 protein, human; 0/Cytoskeletal Proteins; 0/NIMA-interacting peptidylprolyl isomerase; 0/Trans-Activators; 0/beta Catenin; EC 5.2.1.8/Peptidylprolyl Isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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