Document Detail


Pimozide attenuates acquisition of lever-pressing for food in rats.
MedLine Citation:
PMID:  7291269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pimozide pretreatment produced a dose-dependent attenuation of acquisition of a lever-pressing habit motivated by food reward in hungry rats. No evidence of learning was seen in animals treated at 1.0 mg/kg, minimal learning was seen at 0.5 mg/kg, and retarded learning which ultimately did reach normal asymptote was seen at 0.25 mg/kg. Thus primozide attenuates the response acquisition function as well as the previously studied response maintenance function of food reward.
Authors:
R A Wise; H V Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  15     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1981-12-22     Completed Date:  1981-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  655-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant / drug effects*
Depression, Chemical
Food
Male
Pimozide / pharmacology*
Rats
Rats, Inbred Strains
Receptors, Dopamine / drug effects
Chemical
Reg. No./Substance:
0/Receptors, Dopamine; 2062-78-4/Pimozide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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