Document Detail


Pimecrolimus--a safe and effective local immunomodulator in the treatment of inflammatory skin diseases.
MedLine Citation:
PMID:  15788149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pimecrolimus (SDZ ASM 981), an ascomycin derivative, as one of the new classes of immunomodulating macrolactams, is specifically effective in the treatment of inflammatory skin diseases. The interest in pimecrolimus is highly important for its significant anti-inflammatory activity, cell-selective inhibition of inflammatory cytokines, immunomodulatory capabilities, and low systemic immunosuppressive potential. The mechanism of action of pimecrolimus is the blockage of T cell activation, blocking signal transduction pathways in T cells, and inhibition of the synthesis of inflammatory cytokines, specifically Th1- and Th2-type cytokines. Several studies have evaluated the effectiveness of pimecrolimus as the treatment of choice for inflammatory skin diseases.
Authors:
Jasna Lipozencić
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermatovenerologica Croatica : ADC     Volume:  13     ISSN:  1330-027X     ISO Abbreviation:  Acta Dermatovenerol Croat     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-24     Completed Date:  2005-06-15     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  9433781     Medline TA:  Acta Dermatovenerol Croat     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  63-9     Citation Subset:  IM    
Affiliation:
University Department of Dermatology and Venereology Zagreb University Hospital Center, Salata 4, HR-10000 Zagreb, Croatia. jasna.lipozencic@zg.htnet.hr
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MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Dermatitis, Atopic / drug therapy
Eczema / drug therapy
Immunologic Factors / therapeutic use*
Immunosuppressive Agents / therapeutic use*
Inflammation / drug therapy
Psoriasis / drug therapy
Skin Diseases / drug therapy*
Tacrolimus / analogs & derivatives*,  therapeutic use*
Chemical
Reg. No./Substance:
0/Immunologic Factors; 0/Immunosuppressive Agents; 0/pimecrolimus; 109581-93-3/Tacrolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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