Document Detail


Pilot study with a glutamine-supplemented enteral formula in critically ill infants.
MedLine Citation:
PMID:  10488597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seriously ill infants often display protein-calorie malnutrition due to the metabolic demands of sepsis and respiratory failure. Glutamine has been classified as a conditionally essential amino acid, with special usefulness in critical patients. Immunomodulation, gut protection, and prevention of protein depletion are mentioned among its positive effects in such circumstances. With the intent of evaluating the tolerance and clinical impact of a glutamine supplement in seriously ill infants, a prospective randomized study was done with nine patients. Anthropometric and biochemical determinations were made, and length of stay in the intensive care unit (ICU), in the hospital, and under artificial ventilation, and septic morbidity and mortality were tabulated. Infants in the treatment group (n = 5) were enterally administered 0.3 g/kg of glutamine, whereas controls received 0.3 g/kg of casein during a standard period of five days. Septic complications occurred in 75% of the controls (3/4) versus 20% of the glutamine-treated group (1/5, p < or = 0.10), and two patients in the control group died of bacterial infections (50% vs. 0%, p < or = 0.10). Days in the ICU, in the hospital, and with ventilation numerically favored glutamine therapy, although without statistical significance. The supplements were usually well tolerated, and no patient required discontinuation of the program. The conclusion was that glutamine supplementation was safe and tended to be associated with less infectious morbidity and mortality in this high-risk population.
Authors:
E Barbosa; E A Moreira; J E Goes; J Faintuch
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Revista do Hospital das Clínicas     Volume:  54     ISSN:  0041-8781     ISO Abbreviation:  Rev Hosp Clin Fac Med Sao Paulo     Publication Date:    1999 Jan-Feb
Date Detail:
Created Date:  1999-12-13     Completed Date:  1999-12-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0415246     Medline TA:  Rev Hosp Clin Fac Med Sao Paulo     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Affiliation:
Hospital Infantil Joana de Gusmão, Department of Nutrition, Federal University of Santa Catarina.
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Critical Illness*
Dietary Supplements*
Enteral Nutrition / methods*
Female
Glutamine / administration & dosage*
Humans
Infant
Intensive Care Units, Pediatric
Male
Pilot Projects
Prospective Studies
Chemical
Reg. No./Substance:
56-85-9/Glutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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