Document Detail


Pilot study of vaporization of perfluorohexane during high-frequency oscillatory ventilation in experimental acute lung injury.
MedLine Citation:
PMID:  20874224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inhalation of perfluorohexane vapor (PFH) and high-frequency oscillatory ventilation (HFOV) both have been shown to improve lung function in acute lung injury (ALI). Their combination implies synergistic action. The authors investigated technical aspects of PFH vaporization during HFOV and effects on gas exchange in a pilot study of experimental ALI. Eighteen anesthetized sheep were randomly assigned to HFOV or HFOV with PFH inhalation after oleic acid-induced ALI. HFOV was set to a continuous distending pressure of 25 cm H₂O, and an oscillation of 80 to 100 cm H₂O at a frequency of 5 Hz. PFH vapor was delivered by means of bypassed high-flow oxygen through a thin endotracheal tube. PFH concentration was measured by infrared absorption. Blood gases and hemodynamic data were taken. PaO₂ significantly increased from 9.1 ± 0.9 to 32.7 ± 9.5 kPa (mean ± SEM) in the HFOV group and from 12.5 ± 1.1 to 27.0 ± 6.8 kPa in the HFOV PFH group. PaCO₂ significantly decreased from 6.3 ± 0.3 to 5.5 ± 0.5 kPa in the HFOV group and from 5.7 ± 0.4 to 4.9 ± 0.5 kPa in the HFOV PFH group. Changes in gas exchange were not different between groups. These results show that the inhalation of PFH during HFOV is technically feasible, but did not enhance gas exchange in a 210-minute observation period of experimental ALI.
Authors:
Stefan Rasche; Stefan Friedrich; Jörg U Bleyl; Marcelo Gama de Abreu; Thea Koch; Maximilian Ragaller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental lung research     Volume:  36     ISSN:  1521-0499     ISO Abbreviation:  Exp. Lung Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-13     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004944     Medline TA:  Exp Lung Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  538-47     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Dresden, Germany. stefan.rasche@mailbox.tu-dresden.de
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MeSH Terms
Descriptor/Qualifier:
Acute Lung Injury / chemically induced,  drug therapy*,  physiopathology
Animals
Disease Models, Animal
Fluorocarbons / administration & dosage*
High-Frequency Ventilation / methods*
Inhalation Exposure
Liquid Ventilation / methods*
Oleic Acid / toxicity
Pilot Projects
Pulmonary Gas Exchange / drug effects
Sheep
Volatilization
Chemical
Reg. No./Substance:
0/Fluorocarbons; 112-80-1/Oleic Acid; 355-42-0/perfluorohexane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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