| Pilot study of a short course of ribavirin and alpha interferon in the treatment of chronic active hepatitis C not responding to alpha-interferon alone. | |
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MedLine Citation:
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PMID: 9131395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic active hepatitis due to HCV represents a severe progressive disorder of the liver, At present, Interferon seems to be the most efficacious treatment available, however, only 20-25% of the patients treated achieve complete remission. The efficacy has, therefore, been evaluated of Ribavirin, a nucleoside analogue active both on DNA and RNA viruses, in the treatment of non responders to a previous course of interferon. Twenty patients were randomly assigned to two groups: A) received the association R (800 mg/day for 2 months)+interferon (9 Mu/week for 6 months); B) received IFN (9 Mu/week for 6 months). All patients completed the study without important side effects. Four patients in group A presented reduced ALT and loss of viraemia during treatment with Ribavirin. Only one patient in group B had reduced indices of cell lysis and was negative for HCV-RNA during the course of the study. However, viremia and an increase of ALT values were observed in all of these subjects once treatment was interrupted. The results emerging from this study indicate that Ribavirin therapy, at the dose and duration of treatment employed, is not sufficient to change the natural course of events of chronic active hepatitis from HCV. |
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Authors:
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G Scotto; V Fazio; G Tantimonaco |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Italian journal of gastroenterology Volume: 28 ISSN: 0392-0623 ISO Abbreviation: Ital J Gastroenterol Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-07-28 Completed Date: 1997-07-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8000544 Medline TA: Ital J Gastroenterol Country: ITALY |
Other Details:
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Languages: eng Pagination: 505-11 Citation Subset: IM |
Affiliation:
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Divisione di Malattie Infettive, Ospedali Riuniti, Foggia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood Antiviral Agents / administration & dosage, adverse effects, therapeutic use* Dose-Response Relationship, Drug Drug Therapy, Combination Female Follow-Up Studies Hepacivirus / genetics, immunology Hepatitis C / enzymology, pathology, therapy* Hepatitis C Antibodies / analysis Hepatitis, Chronic / enzymology, pathology, therapy* Humans Interferon Type I, Recombinant / administration & dosage, adverse effects, therapeutic use* Male Pilot Projects Polymerase Chain Reaction RNA, Viral / analysis, drug effects Ribavirin / administration & dosage, adverse effects, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Hepatitis C Antibodies; 0/Interferon Type I, Recombinant; 0/RNA, Viral; 36791-04-5/Ribavirin; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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