Document Detail


Pilot study investigating the ability of an herbal composite to alleviate clinical signs of respiratory dysfunction in horses with recurrent airway obstruction.
MedLine Citation:
PMID:  17479778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recurrent airway obstruction (RAO), known previously as chronic obstructive pulmonary disease (COPD), is a debilitating respiratory condition that significantly contributes to lost training days and illness in racehorses. Herbs are becoming increasingly popular for the prophylaxis or treatment of the clinical signs of RAO despite a paucity of research on efficacy and safety. We evaluated the ability of an herbal composite containing garlic, white horehound, boneset, aniseed, fennel, licorice, thyme, and hyssop to reduce the clinical signs of RAO, hypothesizing that the product would safely reduce signs and would improve the inflammatory cell profile within the lungs. The composite was fed to 6 horses with symptomatic RAO for 21 d in a crossover manner. Ventigraphs were used to record respiratory rate and intrapleural pressure; the proportion of inflammatory cells in fluid aspirated from the trachea was determined. Blood biochemical and hematologic screening was conducted to identify possible adverse effects. Treatment with the composite did not result in statistically significant changes in any of the parameters evaluated. A trend to a decrease in respiratory rate (P = 0.1) and an increase in the proportion of macrophages (P = 0.1) was observed in the horses receiving the herbal composite compared with placebo. These data indicate a potential for the herbal composite to safely reduce the elevated respiratory rate in horses with RAO. Future research with a greater number of horses is warranted to further characterize the effect of this product on horses with RAO.
Authors:
Wendy Pearson; Armen Charch; Dyanne Brewer; Andrew F Clarke
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire     Volume:  71     ISSN:  0830-9000     ISO Abbreviation:  Can. J. Vet. Res.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-06-18     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  8607793     Medline TA:  Can J Vet Res     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  145-51     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, Ontario Veterinary College. wpearson@uoguelph.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Chemical Analysis
Bronchoalveolar Lavage Fluid / cytology
Cross-Over Studies
Female
Horse Diseases / drug therapy*,  immunology,  prevention & control
Horses
Lung Diseases, Obstructive / drug therapy,  immunology,  prevention & control,  veterinary*
Male
Phytotherapy / methods,  veterinary*
Pilot Projects
Plant Extracts / adverse effects,  therapeutic use*
Respiratory Function Tests / methods,  veterinary
Safety
Spices
Trachea / cytology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Plant Extracts
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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