Document Detail

Pilot study on the impact of potato chips consumption on biomarkers of acrylamide exposure.
MedLine Citation:
PMID:  16438291     Owner:  NLM     Status:  MEDLINE    
Food is assumed to be one major source of acrylamide exposure in the general population. Acrylamide exposure is usually assessed by measuring hemoglobin adducts of acrylamide and its primary metabolite glycidamide as biomarkers. Little is known about the impact of acrylamide in food on biomarkers of acrylamide exposure. Therefore, CDC is conducting a feeding study to investigate the effect of consumption of endogenous acrylamide in food on biomarkers of acrylamide exposure. As part of this study, we performed a pilot study to obtain further information on the magnitude of the changes in biomarker levels after consumption of high amounts of potato chips (21 ounces) over a short period of time (1 week) in non-smokers. After 1 week, biomarkers levels increased up to 46% for acrylamide adducts and 79% for glycidamide adducts. The results indicate that changes in biomarker levels due to consumption of potato chips can be detected. However, because of the design of this pilot study, the observed magnitude of change cannot be. generalized and needs to be confirmed in the main study.
Hubert W Vesper; Hermes Licea-Perez; Tunde Meyers; Maria Ospina; Gary L Myers
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  561     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2005  
Date Detail:
Created Date:  2006-01-27     Completed Date:  2006-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-96     Citation Subset:  IM    
National Center for Environmental Health, Centers for Disease Control and Prevention, 477 Buford Hwy NE MS F25, Atlanta, GA 30341, USA.
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MeSH Terms
Acrylamide / analysis,  toxicity*
Biological Markers / chemistry*
Chromatography, Liquid
Epoxy Compounds / analysis,  toxicity
Food Analysis
Food Contamination
Hemoglobins / chemistry
Mass Spectrometry
Pilot Projects
Reproducibility of Results
Solanum tuberosum
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Epoxy Compounds; 0/Hemoglobins; 5694-00-8/glycidamide; 79-06-1/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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