| Pilot study of fluzinamide (N-methyl-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide) in refractory partial seizures. | |
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MedLine Citation:
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PMID: 4022365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We conducted a pilot study of fluzinamide in 15 adults with refractory partial seizures. After a baseline period, fluzinamide was added to the existing regimen of phenytoin and carbamazepine and increased to maximum tolerated dose. Common side effects included dizziness, diplopia, ataxia, headache, nausea, and rash, resulting in patient withdrawal in six cases. Seizures became less frequent in four of the nine patients who completed the 8-week trial. |
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Authors:
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P D Donofrio; C Sackellares; J A Madsen; F Matsuo; B Abou-Khalil; S Berent; J Wagner; S B Ater; H Mavor; P E Gay |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 35 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1985 Aug |
Date Detail:
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Created Date: 1985-09-05 Completed Date: 1985-09-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1239-41 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anticonvulsants / therapeutic use Azetidines / administration & dosage, adverse effects, therapeutic use* Azetines / therapeutic use* Central Nervous System Diseases / chemically induced Drug Resistance Gastrointestinal Diseases / chemically induced Humans Liver Function Tests Male Middle Aged Pilot Projects Seizures / classification, drug therapy*, physiopathology Skin Diseases / chemically induced |
| Grant Support | |
ID/Acronym/Agency:
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M01RR00042/RR/NCRR NIH HHS; N01-NS-1-2363/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Azetidines; 0/Azetines; 76263-13-3/fluzinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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