| Pilot study: The effect of reducing treatment on exercise induced bronchoconstriction. | |
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MedLine Citation:
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PMID: 20597080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: Nineteen children, aged 8-16 years, with clinically stable asthma, receiving LABA/ICS combination therapy, were analyzed in this open-label pilot study. Children performed an exercise challenge at baseline and 3 weeks after the medication reduction. Best values of spirometric measurements of the forced expiratory volume in 1 sec (FEV(1)) were used for statistical calculations. RESULTS: Maximum percent fall in FEV(1) was significantly lower after 3 weeks of ICS monotherapy (P = 0.03). Eight of 19 children had a >or=15% fall in FEV(1) after exercise at the initial exercise challenge. In this subgroup, maximum percent fall in FEV(1) after the medication reduction was significantly lower (P < 0.01), and in six children it decreased to <15%, indicating they no longer had EIB. CONCLUSION: In clinically stable asthmatic children on LABA/ICS combination therapy, the cessation of the LABA can reduce and in most cases abolish EIB. |
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Authors:
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E T G Kersten; J M M Driessen; J C van Leeuwen; B J Thio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric pulmonology Volume: 45 ISSN: 1099-0496 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-15 Revised Date: 2011-01-11 |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
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Languages: eng Pagination: 927-33 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatrics, Medisch Spectrum Twente, Enschede, the Netherlands. elinkersten@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adolescent Adrenal Cortex Hormones / administration & dosage* Adrenergic beta-2 Receptor Agonists / administration & dosage* Asthma, Exercise-Induced / drug therapy* Child Drug Administration Schedule Drug Therapy, Combination Female Humans Male Pilot Projects |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Adrenergic beta-2 Receptor Agonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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