| Pilot studies to demonstrate that intestinal mucosal afferent nerves are functionally linked to visceral adipose tissue. | |
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MedLine Citation:
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PMID: 17393331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary capsaicin reduces rodent visceral fat weight. We tested the hypothesis that intact intestinal mucosal afferent nerve function is necessary for fat deposition in visceral adipose tissue sites. Rats were treated daily for 2 weeks with intragastric (chronic treatment) vehicle or capsaicin. Superior mesenteric artery blood flow and mesenteric and inguinal fat blood flow were measured before and after capsaicin was administered into the duodenum (acute treatment). Fat from all sites was dissected and weighed. Chronic capsaicin significantly attenuated acute capsaicin-induced mesenteric hyperemia but did not abolish the reflex wiping of the eye exposed to capsaicin, indicating that functional ablation was limited to the intestinal mucosal afferent nerves. The associated vasoconstriction in adipose tissue was inhibited at the visceral (mesenteric) site and maintained but attenuated at the subcutaneous (inguinal) site. The onset of vasoconstriction was instantaneous, indicating a reflex mechanism. There was a redistribution of fat from visceral to subcutaneous sites, reflected by a decrease and an increase in the percentage of body fat in the visceral and subcutaneous sites, respectively. These pilot studies reveal for the first time that normal intestinal mucosal afferent nerve function is necessary for the physiologic accumulation of fat in visceral adipose tissue sites. |
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Authors:
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Felix W Leung; Vay Liang W Go; Oscar U Scremin; Andre Obenaus; Michael L Tuck; Michael S Golub; Peter Eggena; Joseph W Leung |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2007-03-28 |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 52 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-06 Completed Date: 2007-10-25 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2695-702 Citation Subset: AIM; IM |
Affiliation:
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Research and Medical Services, Sepulveda Ambulatory Care Center and Nursing Home, Sepulveda, California 91343, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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blood supply,
physiology* Analgesics, Non-Narcotic / administration & dosage Animals Blood Flow Velocity Body Weight Capsaicin / administration & dosage Disease Models, Animal Drug Administration Routes Duodenum Intestinal Mucosa / drug effects, innervation* Laser-Doppler Flowmetry Mesenteric Artery, Superior / drug effects, physiology Neurons, Afferent / drug effects, physiology* Obesity / etiology, physiopathology Pilot Projects Rats Rats, Sprague-Dawley Stomach Vasoconstriction / drug effects, physiology Viscera* |
| Grant Support | |
ID/Acronym/Agency:
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1 P01 CA42710/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic; 404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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