Document Detail


Pilot evaluation of citalopram for the treatment of hot flashes in women with inadequate benefit from venlafaxine.
MedLine Citation:
PMID:  16238505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: While newer antidepressants, such as venlafaxine and paroxetine, substantially decrease hot flashes, there is no published information with regards to whether a different antidepressant will be effective when one antidepressant does not adequately relieve hot flashes. OBJECTIVE: The objective of this trial was to provide pilot information with regards to whether citalopram would effectively reduce hot flashes in patients who did not receive adequate enough hot flash reduction with venlafaxine. DESIGN: This was a prospective pilot trial. MEASUREMENTS: Validated patient-completed hot flash diary questionnaires were utilized for measuring hot flashes. SUBJECTS: Thirty patients were recruited to this trial, 22 of whom were fully evaluable. RESULTS: Compared to a baseline week, hot flash scores were reduced by 53% 4 weeks later. The citalopram appeared to be well tolerated with many quality-of-life and potential toxicity symptoms much improved compared to the baseline week. At the end of the 4-week treatment, 19 patients (63% of patients entering the study and 86% of the patient completing the study treatment) chose to continue to use citalopram. CONCLUSION: This pilot information supports the hypothesis that citalopram will reduce hot flashes in patients with inadequate hot flash relief while taking venlafaxine.
Authors:
Charles L Loprinzi; Patrick J Flynn; Lisa A Carpenter; Pam Atherton; Debra L Barton; Tait D Shanafelt; Teresa A Rummans; Jeff A Sloan; Alex A Adjei; Betty A Mincey; Tom R Fitch; Mary Collins
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of palliative medicine     Volume:  8     ISSN:  1096-6218     ISO Abbreviation:  J Palliat Med     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-21     Completed Date:  2006-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808462     Medline TA:  J Palliat Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  924-30     Citation Subset:  IM    
Affiliation:
Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. loprinzi.charles@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Citalopram / pharmacology,  therapeutic use*
Cyclohexanols
Female
Hot Flashes / drug therapy*
Humans
Middle Aged
Pilot Projects
Prospective Studies
Serotonin Uptake Inhibitors / pharmacology,  therapeutic use*
Treatment Failure
Chemical
Reg. No./Substance:
0/Cyclohexanols; 0/Serotonin Uptake Inhibitors; 59729-33-8/Citalopram; 93413-69-5/venlafaxine
Comments/Corrections
Comment In:
J Palliat Med. 2005 Oct;8(5):898-9   [PMID:  16238497 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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