| Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases. | |
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MedLine Citation:
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PMID: 21051715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate blood flow changes in retinal and optic nerve diseases with Doppler Fourier domain optical coherence tomography (OCT). METHODS: Sixty-two participants were divided into five groups: normal, glaucoma, nonarteritic ischemic optic neuropathy (NAION), treated proliferative diabetic retinopathy (PDR), and branch retinal vein occlusion (BRVO). Doppler OCT was used to scan concentric circles of 3.4- and 3.75-mm diameters around the optic nerve head. Flow in retinal veins was calculated from the OCT velocity profiles. Arterial and venous diameters were measured from OCT Doppler and reflectance images. RESULTS: Total retinal blood flow in normal subjects averaged 47.6 μL/min. The coefficient of variation of repeated measurements was 11% in normal eyes and 14% in diseased eyes. Eyes with glaucoma, NAION, treated PDR, and BRVO had significantly decreased retinal blood flow compared with normal eyes (P < 0.001). In glaucoma patients, the decrease in blood flow was highly correlated with the severity of visual field loss (P = 0.003). In NAION and BRVO patients, the hemisphere with more severe disease also had lower blood flow. CONCLUSIONS: Doppler OCT retinal blood flow measurements showed good repeatability and excellent correlation with visual field and clinical presentations. This approach could enhance our understanding of retinal and optic nerve diseases and facilitate the development of new therapies. |
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Authors:
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Yimin Wang; Amani A Fawzi; Rohit Varma; Alfredo A Sadun; Xinbo Zhang; Ou Tan; Joseph A Izatt; David Huang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-11 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 52 ISSN: 1552-5783 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-04-01 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 840-5 Citation Subset: IM |
Affiliation:
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Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Flow Velocity Diabetic Retinopathy / physiopathology* Doppler Effect Female Fourier Analysis Glaucoma / physiopathology* Humans Male Middle Aged Optic Neuropathy, Ischemic / physiopathology* Pilot Projects Regional Blood Flow Retinal Vessels / physiology* Tomography, Optical Coherence* |
| Grant Support | |
ID/Acronym/Agency:
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P30 EY03040/EY/NEI NIH HHS; R01 EY013516/EY/NEI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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