| A pilot study of novel biomarkers in neonates with hypoxic-ischemic encephalopathy. | |
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MedLine Citation:
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PMID: 20736881 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Severe hypoxic-ischemic encephalopathy (HIE) is a devastating condition that can lead to mortality and long-term disabilities in term newborns. No rapid and reliable laboratory test exists to assess the degree of neuronal injury in these patients. We propose two possible biomarkers: 1) phosphorylated axonal neurofilament heavy chain (pNF-H) protein, one of the major subunits of neurofilaments, found only in axonal cytoskeleton of neurons and 2) Ubiquitin C-terminal hydrolase 1 (UCHL1 protein) that is heavily and specifically concentrated in neuronal perikarya and dendrites. High-serum pNF-H and UCHL1 levels are reported in subarachnoid hemorrhage and traumatic brain injury, suggesting that they are released into blood following neuronal injury. We hypothesized that serum pNF-H and UCHL1 were higher in neonates with moderate-to-severe HIE than in healthy neonates. A time-limited enrollment of 14 consecutive patients with HIE and 14 healthy controls was performed. UCHL1 and pNF-H were correlated with clinical data and brain MRI. UCHL1 and pNF-H serum levels were higher in HIE versus controls. UCHL1 showed correlation with the 10-min Apgar score, and pNF-H showed correlation with abnormal brain MRI. Our findings suggest that serum UCHL1 and pNF-H could be explored as diagnostic and prognostic tools in neonatal HIE. ABBREVIATIONS:: |
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Authors:
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Martha Douglas-Escobar; Cui Yang; Jeffrey Bennett; Jonathan Shuster; Douglas Theriaque; Avital Leibovici; David Kays; Tong Zheng; Candace Rossignol; Gerry Shaw; Michael D Weiss |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric research Volume: 68 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-07-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 531-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics [M.D.-E.], Baylor College of Medicine, Houston, Texas 77030; Departments of Neuroscience [C.Y., T.Z., G.S.], Neuroradiology [J.B.], Epidemiology and Health Policy Research [J.S.], Pediatrics [A.L., C.R., M.D.W.], and Pediatric Surgery [D.K.], University of Florida, Gainesville, Florida 32611; Clinical and Translational Science Institute [J.S., D.T.], University of Florida, Gainesville, Florida 32610. |
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