| A pilot study of the clinical relevance of the relationship between the serum level of pregnancy-associated plasma protein A and the degree of acute coronary syndrome. | |
| | |
MedLine Citation:
|
PMID: 20515576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Serum levels of pregnancy-associated plasma protein-A (PAPP-A), high-sensitivity C-reactive protein (hs-CRP) and tumour necrosis factor-alpha (TNF-alpha) were measured in 70 patients with acute coronary syndrome (ACS), comprising 18 with unstable angina (UA), 37 with acute myocardial infarction (AMI) and 15 with stable angina (SA); 15 healthy controls were also included. Levels of PAPP-A were significantly higher in the UA and AMI groups than in the SA and control groups. Levels of PAPP-A were similar in the SA and control groups, and higher in the ACS patients who were cardiac troponin T-negative (comprising UA and AMI patients) than in the control and SA groups. Levels of hs-CRP and TNF-alpha were significantly higher in the SA group than in the control group, significantly higher in the UA group than in the SA and control groups, and significantly higher in the AMI group than in all other groups. Levels of PAPP-A in ACS patients were positively correlated with levels of hs-CRP and TNF-alpha. It would seem, therefore, that PAPP-A is associated with inflammation and might be used to detect plaque instability and rupture before an increase in cardiac troponin T is detectable. |
| | |
Authors:
|
L You; L Li; F Zhang; Q Xu; J Ren |
Related Documents
:
|
11247616 - What are appropriate rates of invasive procedures following acute myocardial infarction... 1598866 - Echocardiographic algorithms for admission and predischarge prediction of mortality in ... 20586826 - The p-selectin gene polymorphism val168met: a novel risk marker for the occurrence of p... 20864196 - Carvedilol administration in acute myocardial infarction results in stronger inhibition... 21128936 - Lymphatic vasculature is increased in heart valves, ischaemic and inflamed hearts and i... 2203556 - Circadian variation of acute myocardial infarction and the effect of low-dose aspirin i... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of international medical research Volume: 38 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2010 Mar-Apr |
Date Detail:
|
Created Date: 2010-06-02 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
|
Languages: eng Pagination: 625-32 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular Medicine, Affiliated Zhongnan Hospital of Wuhan University, Wuhan, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Coronary Syndrome
/
blood*,
pathology Angina, Unstable / blood*, pathology C-Reactive Protein / metabolism Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged Pilot Projects Pregnancy Pregnancy-Associated Plasma Protein-A / metabolism* Prognosis Survival Rate Tumor Markers, Biological / blood* Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Tumor Markers, Biological; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Significance of nm23 Immunoexpression in the Prognosis of Renal Cell Carcinoma.
Next Document: Incidental Non-secreting Adrenal Masses in Cancer Patients: Intra-individual Comparison of (18)F-Flu...