Document Detail

Pilomyxoid astrocytoma in a patient with neurofibromatosis.
MedLine Citation:
PMID:  15800886     Owner:  NLM     Status:  MEDLINE    
Pilomyxoid astrocytoma (PMA), a recently described variant of low-grade astrocytoma is associated with a high rate of recurrence and a propensity for CSF seeding. While cases of PMA have been reported in infants and young children, there has been no report of PMA in patients with neurofibromatosis. The first reportable case of PMA occurring in a child with neurofibromatosis type 1 (NF1) is described. Following presentation with obstructive hydrocephalus, the patient underwent a partial resection of a third ventricular tumor. Histology confirmed the typical features of PMA. The patient demonstrated a partial response to chemotherapy. The authors review the literature on PMA and discuss the specific issues associated with this diagnosis in the context of a child with neurofibromatosis.
Muhammad Faisal Khanani; Cynthia Hawkins; Manohar Shroff; Peter Dirks; Michael Capra; P C Burger; Eric Bouffet
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  46     ISSN:  1545-5009     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-04-13     Revised Date:  2009-01-12    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-80     Citation Subset:  IM    
Department of Hematology Oncology, Paediatric Brain Tumor Programme, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Astrocytoma / complications,  pathology,  surgery*
Cerebral Ventricle Neoplasms / complications,  pathology,  surgery*
Hydrocephalus / etiology,  pathology,  surgery
Neoplasms, Second Primary / pathology,  surgery*
Neurofibromatosis 1 / complications,  pathology,  surgery*

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