Document Detail

Pilomatrix carcinoma with multiple metastases: report of a case and review of the literature.
MedLine Citation:
PMID:  10448295     Owner:  NLM     Status:  MEDLINE    
Pilomatrix carcinoma, the malignant counterpart of pilomatrixoma, is rare, with only 55 cases reported, and only four cases with visceral metastases described in the literature. Here we present a case report and a literature review on this rare tumour. A 74-year-old male with a pilomatrix carcinoma from the left temporal region presented in July 1996 and the tumour was excised. One month after diagnosis, metastases to both lungs and to a regional lymph node were found and histologically verified. The patient also developed metastases in the abdomen, back and thoracic spine. The latter resulted in spinal cord compression and paraplegia. Despite systemic chemotherapy with intravenous cisplatin and 5-fluorouracil and localised radiotherapy to the thoracic spine, progression and deterioration led to death within 3 months from time of diagnosis. Pilomatrix carcinomas are usually indolent. In our patient, however, the malignant disease progressed rapidly and it appeared to be resistant to both chemotherapy and irradiation.
R M Bremnes; J M Kvamme; H Stalsberg; E A Jacobsen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  35     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-08-23     Completed Date:  1999-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  433-7     Citation Subset:  IM    
Department of Oncology, University Hospital of Tromsø, Norway.
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MeSH Terms
Abdominal Neoplasms / secondary*
Fatal Outcome
Hair Diseases / pathology*
Lung Neoplasms / secondary*
Magnetic Resonance Imaging
Pilomatrixoma / secondary*,  therapy
Skin Neoplasms / pathology*,  therapy
Spinal Neoplasms / secondary*
Tomography, X-Ray Computed

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