Document Detail

Pilocarpine toxicity and the treatment of xerostomia.
MedLine Citation:
PMID:  15093850     Owner:  NLM     Status:  MEDLINE    
Pilocarpine has been used as an ophthalmologic agent for decades; however, toxicity rarely has been reported in the medical literature. Oral pilocarpine tablets, as well as another muscarinic agent (cevimeline), have recently been approved for the treatment of dry mouth (xerostomia). We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome. The patient's symptoms were relieved with 0.5 mg intravenous atropine and she recovered uneventfully. The case is unique in that it is the first reported ingestion of oral pilocarpine tablets and the first dosing error reported for this indication. In addition, this case underscores the importance of communication between physician and patient and the resulting toxicity related to miscommunication.
Robert G Hendrickson; Anthony P Morocco; Michael I Greenberg
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of emergency medicine     Volume:  26     ISSN:  0736-4679     ISO Abbreviation:  J Emerg Med     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8412174     Medline TA:  J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
Department of Emergency Medicine, Oregon Poison Center, Oregon Health and Sciences University, Portland, Oregon 97201-3098, USA.
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MeSH Terms
Administration, Oral
Middle Aged
Muscarinic Agonists / administration & dosage,  poisoning*
Pilocarpine / administration & dosage,  poisoning*
Sjogren's Syndrome / complications
Xerostomia / drug therapy*,  etiology
Reg. No./Substance:
0/Muscarinic Agonists; 92-13-7/Pilocarpine

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