Document Detail

Pili and flagella biology, structure, and biotechnological applications.
MedLine Citation:
PMID:  21999994     Owner:  NLM     Status:  MEDLINE    
Bacteria and Archaea expose on their outer surfaces a variety of thread-like proteinaceous organelles with which they interact with their environments. These structures are repetitive assemblies of covalently or non-covalently linked protein subunits, organized into filamentous polymers known as pili ("hair"), flagella ("whips") or injectisomes ("needles"). They serve different roles in cell motility, adhesion and host invasion, protein and DNA secretion and uptake, conductance, or cellular encapsulation. Here we describe the functional, morphological and genetic diversity of these bacterial filamentous protein structures. The organized, multi-copy build-up and/or the natural function of pili and flagella have lead to their biotechnological application as display and secretion tools, as therapeutic targets or as molecular motors. We review the documented and potential technological exploitation of bacterial surface filaments in light of their structural and functional traits.
Nani Van Gerven; Gabriel Waksman; Han Remaut
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in molecular biology and translational science     Volume:  103     ISSN:  1878-0814     ISO Abbreviation:  Prog Mol Biol Transl Sci     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-17     Completed Date:  2013-06-06     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101498165     Medline TA:  Prog Mol Biol Transl Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  21-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Archaea / metabolism
Bacterial Proteins / secretion
Biotechnology / methods*
Fimbriae, Bacterial / chemistry*,  metabolism
Flagella / chemistry*,  metabolism
Organelles / metabolism
Grant Support
G0800002//Medical Research Council
Reg. No./Substance:
0/Bacterial Proteins

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