Document Detail


Pigtailed macaque model refinement: topical microbicide safety in the presence of coitus.
MedLine Citation:
PMID:  21443565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Inclusion of sexual activity in the macaque model for topical microbicide safety evaluation would more closely mimic human use of topical microbicides and provide a more rigorous safety assessment.
METHODS: Initially, male-female partners were monitored in cohousing arrangements to determine whether macaques would copulate ad libitum. The logistics of performing vaginal examinations before and after coital visits were analyzed and optimized. Findings from cervicovaginal examinations conducted before and after sexual activity were compared.
RESULTS: Coital activity was reliably observed in the majority of cohousing sessions, representing all phases of the menstrual cycle. Female macaques were trained to be restrained while fully alert for pre-coital vaginal sampling. Post-coital examinations occur under general sedation. Post-coital examinations reveal alterations to tissues, microbiology, and pH compared with pre-coital visits.
CONCLUSIONS: This work clearly demonstrates that it is feasible to incorporate sexual activity in the macaque model for topical microbicide safety assessment.
Authors:
Yvonne T Cosgrove Sweeney; Ray O Angeles; Peter K Cummings; April D Smith; Dorothy L Patton
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Publication Detail:
Type:  Journal Article     Date:  2011-03-28
Journal Detail:
Title:  Journal of medical primatology     Volume:  40     ISSN:  1600-0684     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-28     Completed Date:  2012-02-02     Revised Date:  2014-10-12    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  327-34     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
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MeSH Terms
Descriptor/Qualifier:
Administration, Intravaginal
Animals
Anti-Infective Agents, Local / administration & dosage,  adverse effects*,  pharmacology
Copulation*
Disease Models, Animal*
Drug Evaluation, Preclinical / veterinary
Female
Gynecological Examination / veterinary*
Macaca nemestrina*
Male
Sexually Transmitted Diseases / drug therapy,  microbiology,  prevention & control*
Vagina / drug effects*,  microbiology,  physiology
Grant Support
ID/Acronym/Agency:
R21 AI071939/AI/NIAID NIH HHS; R21 AI071939-02/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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