| Pigmented contact dermatitis due to therapeutic sensitizer as complication of contact immunotherapy in alopecia areata. | |
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MedLine Citation:
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PMID: 20860739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pigmentary complication by contact immunotherapy (CI) for alopecia areata (AA) has been reported but its pathophysiology remains unknown. To characterize pigmentary complication by CI and its pathophysiology, we examined the incidence of hyperpigmentation in 186 consecutive patients treated with CI using diphenylcyclopropenone. From clinical data of AA totalis (AAT) or universalis (AAU) patients (n = 78), we studied the correlations between this complication and age, sex, atopic background, duration and treatment responsiveness, duration of CI, final concentration of diphenylcyclopropenone and administration of anti-histamines by χ(2)-test or Mann-Whitney U-test. Additionally, the histopathology of pigmentation was studied. As a result, 11 (5.91%) of the 186 patients had hyperpigmentation in this series. All of them had AAT or AAU, suggesting that the pigmentation is apt to occur in severe AA. When the AAT or AAU patients with (n = 11) and without hyperpigmentation (n = 67) were compared, those with pigmentation showed poorer responsiveness to CI (P < 0.05) but no significant tendency for other factors. Histopathologically, skin specimens showed lichenoid or vacuolar interface dermatitis with necrotic keratinocytes and dermal melanophages, consistent with pigmented contact dermatitis (PCD). Together, pigmentary complication by CI corresponds to PCD from therapeutic sensitizer, representing clinical indicator of poor responsiveness. |
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Authors:
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Shigeki Inui; Takeshi Nakajima; Naoyuki Toda; Satoshi Itami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 37 ISSN: 1346-8138 ISO Abbreviation: J. Dermatol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-23 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 888-93 Citation Subset: IM |
Copyright Information:
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© 2010 Japanese Dermatological Association. |
Affiliation:
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Department of Regenerative Dermatology, Osaka University School of Medicine, Suita, Osaka, Japan. inui@r-derma.med.osaka-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Alopecia Areata / therapy* Child Cyclopropanes / adverse effects* Dermatitis, Contact / etiology* Dermatologic Agents / adverse effects* Female Humans Hyperpigmentation / chemically induced*, pathology Immunotherapy / adverse effects* Male Middle Aged Severity of Illness Index Statistics, Nonparametric Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cyclopropanes; 0/Dermatologic Agents; 886-38-4/diphenylcyclopropenone |
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