Document Detail

Pigmented "black" pheochromocytoma of the adrenal gland: a case report and review of the literature.
MedLine Citation:
PMID:  15387689     Owner:  NLM     Status:  MEDLINE    
A pigmented "black" mass was discovered incidentally in a 72-year-old woman. The tumor, which was detected near the upper pole of the left kidney, was cystic and intensely black throughout with the presence of abundant, coarse, dark brown to black pigment granules. Histologic examination showed a proliferation of monomorphous neoplastic cells arranged in a typical zellballen growth pattern. These features indicated a diagnosis of pheochromocytoma. Immunostains for chromogranin A, synaptophysin, and neuron-specific enolase were positive. The immunostain for HMB-45 was negative. Electron microscopy showed neurosecretory-type granules and larger pleomorphic granules, which were considered most consistent with neuromelanin, a waste product of catecholamine metabolism. The evidence of melanin or melanin-like pigment in the adrenal gland has been described in only 10 cases in the literature and is always a microscopic finding. The case reported here is unique for the characteristic black macroscopic appearance and the abundance of pigment.
Guido Bellezza; Michele Giansanti; Antonio Cavaliere; Angelo Sidoni
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  128     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-24     Completed Date:  2005-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e125-8     Citation Subset:  AIM; IM    
Institute of Pathological Anatomy and Histology, Division of Cancer Research, Perugia Medical School, University of Perugia, Italy.
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MeSH Terms
Adrenal Gland Neoplasms / diagnosis*
Pheochromocytoma / diagnosis*

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