Document Detail


Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema.
MedLine Citation:
PMID:  20714746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We investigated whether pigment epithelium-derived factor (PEDF) or vascular endothelial growth factor (VEGF) influence macular edema in patients with branch retinal vein occlusion (BRVO). This investigation aimed to clarify the influence of PEDF in the vitreous fluid on retinal vascular permeability in patients with macular edema secondary to BRVO. The findings were expected to be useful for the treatment of macular edema in BRVO patients.
METHODS: This was a retrospective cross-sectional comparative case series. Thirty-three BRVO patients with macular edema and 24 control patients with nonischemic ocular diseases were enrolled. Retinal ischemia was evaluated by measuring the area of capillary nonperfusion on fluorescein angiography with Scion Image software. Macular edema was examined by optical coherence tomography. Vitreous fluid samples were obtained via pars plana vitrectomy, and the VEGF and PEDF levels were determined by enzyme-linked immunosorbent assay.
RESULTS: The vitreous level of VEGF was significantly higher in BRVO patients than controls (P < 0.001). The vitreous PEDF level was significantly lower in BRVO patients than controls (P = 0.026). In BRVO patients, vitreous levels of PEDF and VEGF showed a significant negative correlation with each other (P < 0.001). Additionally, the vitreous VEGF level had a significant positive correlation (P < 0.001) and the vitreous PEDF level had a significant negative correlation (P < 0.001) with the nonperfused retinal area in BRVO patients. Furthermore, vitreous levels of VEGF and PEDF showed significant positive (P = 0.001) and negative (P = 0.014) correlations, respectively, with macular edema in BRVO patients.
CONCLUSIONS: VEGF and PEDF may inversely influence retinal vascular permeability in patients with ischemic BRVO and macular edema. However, prospective validation will be needed to confirm these observations.
Authors:
Hidetaka Noma; Hideharu Funatsu; Tatsuya Mimura; Seiyo Harino; Shuichiro Eguchi; Sadao Hori
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-08-17
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  248     ISSN:  1435-702X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2010-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1559-65     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, 477-96, Owada-shinden, Yachiyo, Chiba, 276-8524, Japan. nomahide@tymc.twmu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Capillary Permeability
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Eye Proteins / metabolism*
Female
Fluorescein Angiography
Humans
Macular Edema / diagnosis,  metabolism*,  surgery
Male
Nerve Growth Factors / metabolism*
Retinal Vein Occlusion / diagnosis,  metabolism*,  surgery
Retrospective Studies
Serpins / metabolism*
Vascular Endothelial Growth Factor A / metabolism*
Vitrectomy
Vitreous Body / metabolism*
Chemical
Reg. No./Substance:
0/Eye Proteins; 0/Nerve Growth Factors; 0/Serpins; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 0/pigment epithelium-derived factor

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