| Piecewise affine systems approach to control of biological networks. | |
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MedLine Citation:
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PMID: 20921007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In terms of a piecewise affine system representation, which is a kind of hybrid system model, this article discusses a series of approaches to modelling, analysing and synthesizing a biological network such as a gene-regulatory network. First, the input assignment problem, the controllable state set problem (CSP) and the input trajectory generation problem are emphasized as control problems to be addressed for biological networks. Subsequently, after the modelling issue on biological networks developed in the systems and control community is briefly explained, the CSP is described in detail with reference to control of the quorum-sensing system in the pathogen Pseudomonas aeruginosa. Finally, an optimal control design method to the quorum-sensing system is proposed as a solution to the input trajectory generation problem. |
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Authors:
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Jun-Ichi Imura; Kenji Kashima; Masami Kusano; Tsukasa Ikeda; Tomohiro Morohoshi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Volume: 368 ISSN: 1364-503X ISO Abbreviation: Philos Transact A Math Phys Eng Sci Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101133385 Medline TA: Philos Transact A Math Phys Eng Sci Country: England |
Other Details:
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Languages: eng Pagination: 4977-93 Citation Subset: IM |
Affiliation:
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Department of Mechanical and Environmental Informatics, Graduate School of Information Science and Engineering, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8552, Japan. imura@mei.titech.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Gene Expression Regulation* Models, Biological* Nonlinear Dynamics* Pseudomonas aeruginosa / growth & development Quorum Sensing / physiology Signal Transduction* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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