Document Detail


Piecemeal degranulation in human eosinophils: a distinct secretion mechanism underlying inflammatory responses.
MedLine Citation:
PMID:  20712018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secretion is a fundamental cell process underlying different physiological and pathological events. In cells from the human immune system such as eosinophils, secretion of mediators generally occurs by means of piecemeal degranulation, an unconventional secretory pathway characterized by vesicular transport of small packets of materials from the cytoplasmic secretory granules to the cell surface. During piecemeal degranulation in eosinophils, a distinct transport vesicle system, which includes large, pleiomorphic vesiculo-tubular carriers is mobilized and enables regulated release of granule-stored proteins such as cytokines and major basic protein. Piecemeal degranulation underlies distinct functions of eosinophils as effector and immunoregulatory cells. This review focuses on the structural and functional advances that have been made over the last years concerning the intracellular trafficking and secretion of eosinophil proteins by piecemeal degranulation during inflammatory responses.
Authors:
Rossana C N Melo; Peter F Weller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Histology and histopathology     Volume:  25     ISSN:  1699-5848     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-16     Completed Date:  2010-12-07     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  1341-54     Citation Subset:  IM    
Affiliation:
Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, UFJF, Juiz de Fora, MG, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Cell Degranulation*
Cytokines / metabolism*,  secretion
Eosinophils / immunology*,  secretion,  ultrastructure
Humans
Inflammation / immunology*,  pathology
Inflammation Mediators / metabolism*
Transport Vesicles / metabolism
Grant Support
ID/Acronym/Agency:
AI020241/AI/NIAID NIH HHS; AI022571/AI/NIAID NIH HHS; AI051645/AI/NIAID NIH HHS; R01 AI022571/AI/NIAID NIH HHS; R01 AI022571-23/AI/NIAID NIH HHS; R01 AI051645-09/AI/NIAID NIH HHS; R37 AI020241-27/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators
Comments/Corrections

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