| Piecemeal degranulation in human eosinophils: a distinct secretion mechanism underlying inflammatory responses. | |
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MedLine Citation:
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PMID: 20712018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secretion is a fundamental cell process underlying different physiological and pathological events. In cells from the human immune system such as eosinophils, secretion of mediators generally occurs by means of piecemeal degranulation, an unconventional secretory pathway characterized by vesicular transport of small packets of materials from the cytoplasmic secretory granules to the cell surface. During piecemeal degranulation in eosinophils, a distinct transport vesicle system, which includes large, pleiomorphic vesiculo-tubular carriers is mobilized and enables regulated release of granule-stored proteins such as cytokines and major basic protein. Piecemeal degranulation underlies distinct functions of eosinophils as effector and immunoregulatory cells. This review focuses on the structural and functional advances that have been made over the last years concerning the intracellular trafficking and secretion of eosinophil proteins by piecemeal degranulation during inflammatory responses. |
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Authors:
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Rossana C N Melo; Peter F Weller |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Histology and histopathology Volume: 25 ISSN: 1699-5848 ISO Abbreviation: Histol. Histopathol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-07 Revised Date: 2011-05-05 |
Medline Journal Info:
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Nlm Unique ID: 8609357 Medline TA: Histol Histopathol Country: Spain |
Other Details:
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Languages: eng Pagination: 1341-54 Citation Subset: IM |
Affiliation:
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Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, UFJF, Juiz de Fora, MG, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Degranulation* Cytokines / metabolism*, secretion Eosinophils / immunology*, secretion, ultrastructure Humans Inflammation / immunology*, pathology Inflammation Mediators / metabolism* Transport Vesicles / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AI020241/AI/NIAID NIH HHS; AI022571/AI/NIAID NIH HHS; AI051645/AI/NIAID NIH HHS; R01 AI022571-23/AI/NIAID NIH HHS; R01 AI051645-09/AI/NIAID NIH HHS; R37 AI020241-27/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Inflammation Mediators |
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