Document Detail

Piecemeal degranulation as a general secretory mechanism?
MedLine Citation:
PMID:  12923888     Owner:  NLM     Status:  MEDLINE    
In this article we review the ultrastructural findings, functional aspects, and biological significance of piecemeal degranulation (PMD), a unique secretory pathway that has been described in basophils, mast cells, and eosinophils. Recent ultrastructural data suggestive of PMD in enteroendocrine cells of the gastrointestinal tract and chromaffin cells of the adrenal medulla are also presented and discussed. Further research on PMD in secretory cells of the endocrine and exocrine glands, as well as in neurons, is recommended, since the current data indicate that PMD has a broader spectrum of expression than was hitherto reported. The identification of the PMD phenotype in different cell types (e.g., basophils, mast cells, eosinophils, enteroendocrine cells, and adrenal chromaffin cells) suggests that PMD is a unique degranulation model for paracrine and endocrine secretion. Further investigation will clarify whether PMD can be considered as a general mechanism for the slow release of bioactive stored materials by granulated secretory cells.
Enrico Crivellato; Beatrice Nico; Franco Mallardi; Carlo Alberto Beltrami; Domenico Ribatti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology     Volume:  274     ISSN:  1552-4884     ISO Abbreviation:  -     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101234285     Medline TA:  Anat Rec A Discov Mol Cell Evol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  778-84     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Department of Medical and Morphological Research, University of Udine School of Medicine, Udine, Italy.
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MeSH Terms
Basophils / physiology
Cell Degranulation / physiology*
Endocrine Glands / cytology*,  physiology*,  ultrastructure
Eosinophils / physiology
Mast Cells / physiology

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