Document Detail


Pictorial review of mucopolysaccharidosis with emphasis on MRI features of brain and spine.
MedLine Citation:
PMID:  21511751     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mucopolysaccharidosis (MPS) is an inherited metabolic disorder of childhood, characterised by progressive multisystem involvement predominantly affecting the skeletal system leading to skeletal dysplasia. Mental retardation, neuropathy and cardiomyopathy may occur in the most severely affected patients, leading to progressive disability and death in their early third to fourth decades. The purpose of this paper is to illustrate the typical imaging features of different types of MPS, in particular the MR features of the brain and spine in MPS, which are expected to be encountered by radiologists more frequently in their clinical practice as a result of prolonged life expectancy for those with MPS with recent advances in therapeutic interventions. The treatment options and outcomes for MPS patients are also briefly discussed.
Authors:
D D Rasalkar; W C W Chu; J Hui; C-M Chu; B K Paunipagar; C-K Li
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of radiology     Volume:  84     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-06-13     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-77     Citation Subset:  AIM; IM    
Affiliation:
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Ngan Shing St, Shatin, New Territories, Hong Kong.
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MeSH Terms
Descriptor/Qualifier:
Bone Diseases, Developmental / classification,  diagnosis*
Child
Child, Preschool
Enzyme Therapy / methods
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Mucopolysaccharidoses / classification,  diagnosis*
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