Document Detail


Pica as an adaptive response: Kaolin consumption helps rats recover from chemotherapy-induced illness.
MedLine Citation:
PMID:  19419663     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clay consumption can occur during illness but there has been little work to understand why. To investigate whether consuming clay confers an advantage to the sick animal, we compared the recovery from illness of adult male rats with or without access to kaolin. Illness was induced by injection of 6 mg/kg, ip, cisplatin, a toxic chemotherapy agent, and recovery was assessed by changes in daily food intake, water intake, and body weight. Relative to saline-injected controls, cisplatin-injected rats reduced food and water intake and lost weight. However, those with access to kaolin ate more food and lost less body weight than did those without access to kaolin. Thus, clay consumption appeared beneficial in that it either protected the rats from illness or enhanced recovery and might prove useful as an adjunct therapy for other animals, including humans, experiencing visceral malaise.
Authors:
Bart C De Jonghe; Maureen P Lawler; Charles C Horn; Michael G Tordoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-02-11
Journal Detail:
Title:  Physiology & behavior     Volume:  97     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-06-23     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Cisplatin / poisoning*
Drinking / drug effects
Drug Interactions
Eating / drug effects
Kaolin / pharmacology*
Male
Pica*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DC000014/DC/NIDCD NIH HHS; DK065971/DK/NIDDK NIH HHS; DK46791/DK/NIDDK NIH HHS; R01 DK065971/DK/NIDDK NIH HHS; R01 DK065971-04/DK/NIDDK NIH HHS; R01 DK065971-05/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
24H4NWX5CO/Kaolin; Q20Q21Q62J/Cisplatin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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