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PI3Kγ IN HYPERTENSION: A NOVEL THERAPEUTIC TARGET CONTROLLING VASCULAR MYOGENIC TONE AND TARGET ORGAN DAMAGE.
MedLine Citation:
PMID:  22610309     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the last decade, several studies have characterized a number of cellular and molecular mechanisms contributing to the regulation of vascular myogenic response, thus affecting blood pressure regulation. More recent data, have recently identified phosphoinositide 3-kinase γ (PI3Kγ) as a main regulator of vascular myogenic tone and blood pressure, a result further strengthened by a highly significant genome wide association of a SNP flanking this gene with blood pressure regulation, in a large human population.The goal of this review is to summarize the available information regarding the mechanistic contributions clarifying how PI3Kγ exerts blood pressure control regulating myogenic tone at the level of L-type calcium channel in smooth muscle cells. Moreover, an overview of the pharmacological approaches available for targeting this signaling pathway will show if PI3Kγ emerges as a suitable candidate for antihypertensive therapy, capable to lower blood pressure. Finally, a survey of the studies dissecting the role of PI3Kγ in pathological conditions that are typically induced by hypertension in its target organs, will allow a more complete picture of the high potential of this novel therapeutic approach for fighting hypertension and, at same time, its target organ damage, independently of blood pressure lowering effects.
Authors:
Daniela Carnevale; Giuseppe Lembo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-19
Journal Detail:
Title:  Cardiovascular research     Volume:  -     ISSN:  1755-3245     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli , Italy.
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