Document Detail

Pi MZ phenotype and an increased prevalence of reported psoriasis in a community survey.
MedLine Citation:
PMID:  3489666     Owner:  NLM     Status:  MEDLINE    
In a community survey of 953 adults we identified 40 who reported having had psoriasis. Eight of these cases were subsequently documented from physicians' records. alpha 1-Antitrypsin (alpha 1-AT) phenotyping identified 35 MZ individuals, 4 (11.4%) of whom reported psoriasis. Among the 918 non-MZ individuals 36 (3.9%) reported psoriasis, yielding a relative incidence of 3.2 (p less than 0.05). This is consistent with previous reports suggesting an association between moderate alpha 1-AT deficiency and psoriasis.
S L Horne; G J Junk; D W Cockcroft; A Lovegrove; J A Dosman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human heredity     Volume:  36     ISSN:  0001-5652     ISO Abbreviation:  Hum. Hered.     Publication Date:  1986  
Date Detail:
Created Date:  1986-11-10     Completed Date:  1986-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0200525     Medline TA:  Hum Hered     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  266-8     Citation Subset:  IM    
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MeSH Terms
Epidemiologic Methods
Gene Frequency
Middle Aged
Psoriasis / blood,  epidemiology,  genetics*
alpha 1-Antitrypsin / genetics*
alpha 1-Antitrypsin Deficiency
Reg. No./Substance:
0/alpha 1-Antitrypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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