| Phytopreventative anti-hyperlipidemic effects of gynostemma pentaphyllum in rats. | |
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MedLine Citation:
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PMID: 16401396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Gynostemma pentaphyllum is widely used in traditional Chinese medicine. Preliminary studies indicate Gynostemma isolated triterpine glycosides lower cholesterol. Our studies examine anti-hyperlipidemic effects of gypenosides. METHODS: Gynostemma activity was examined in poloxamer P407 induced hyperlipidemia in rats. RESULTS: 1 g/kg P407 induced plasma triglyceride (25 fold), total cholesterol (6 fold), low density lipoprotein cholesterol (LDL) (7 fold), high density lipoprotein cholesterol (HDL) (1.6 fold), and nitrite (8 fold). After acute (4 days) and chronic (12 days) oral administration the gypenoside extract (250 mg/kg) reduced triglyceride (53% and 85%, respectively) and total cholesterol levels (10% and 44%, respectively). No significant effects on LDL or HDL cholesterol were observed. The gypenosides reduced nitrite approximately 80%. Similar results were obtained with atorvastatin (75 mg/kg for 4 days); except that LDL cholesterol was reduced (17%) and HDL cholesterol increased. 50% of lipoprotein lipase (LPL) plasma activity was inhibited by approximately 20 microM P407. Gynostemma had no effect on LL, however, it reversed the P407 inhibition of LPL activity in a concentration-dependent manner, with a 2-fold increase at approximately 10 microg/ml. CONCLUSIONS: These studies demonstrate efficacy of Gynostemma pentaphyllum in lowering triglyceride, cholesterol and nitrite in acute hyperlipidemia. The results suggest further investigations of Gynostemma gypenosides are warranted to examine the mechanisms of this activity. |
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Authors:
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Samer Megalli; Fugen Aktan; Neal M Davies; Basil D Roufogalis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-16 |
Journal Detail:
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Title: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques Volume: 8 ISSN: 1482-1826 ISO Abbreviation: J Pharm Pharm Sci Publication Date: 2005 |
Date Detail:
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Created Date: 2006-01-10 Completed Date: 2006-04-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9807281 Medline TA: J Pharm Pharm Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 507-15 Citation Subset: IM |
Affiliation:
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Herbal Medicines Research and Education Centre, Faculty of Pharmacy, University of Sydney, Sydney NSW, Australia. smegalli@pharm.usyd.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / therapeutic use* Dose-Response Relationship, Drug Gynostemma* Hyperlipidemias / blood, prevention & control* Male Phytotherapy / methods* Plant Extracts / therapeutic use Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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